A role for CD5 in TCR-mediated signal transduction and thymocyte selection
about
Molecular cloning, mapping to human chromosome 1 q21-q23, and cell binding characteristics of Spalpha, a new member of the scavenger receptor cysteine-rich (SRCR) family of proteinsTCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversityNaïve T Cell Homeostasis Regulated by Stress Responses and TCR SignalingFunctional Heterogeneity in CD4(+) T Cell Responses Against a Bacterial PathogenInteraction of the CD5 cytoplasmic domain with the Ca2+/calmodulin-dependent kinase IIdeltaNegative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3Presenilins regulate alphabeta T cell development by modulating TCR signalingBCL11B is required for positive selection and survival of double-positive thymocytesSeveral different cell surface molecules control negative selection of medullary thymocytesThe tyrosine phosphatase SHP-1 influences thymocyte selection by setting TCR signaling thresholds.MHC class II deprivation impairs CD4 T cell motility and responsiveness to antigen-bearing dendritic cells in vivo.Determination of the tyrosine phosphorylation sites in the T cell transmembrane glycoprotein CD5.Ubc9 Is Required for Positive Selection and Late-Stage Maturation of Thymocytes.Altered thymic positive selection and intracellular signals in Cbl-deficient micePhospholipase C{gamma}1 is essential for T cell development, activation, and toleranceThe MHC class II ligand lymphocyte activation gene-3 is co-distributed with CD8 and CD3-TCR molecules after their engagement by mAb or peptide-MHC class I complexes.CD5 expression by B lymphocytes and its regulation upon Epstein-Barr virus transformation.The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells.Greater frequency of CD5-negative CD8(+) T cells against human immunodeficiency virus type 1 than other viruses is consistent with adaptation to antigenic variation.Recent progress in the understanding of B-cell functions in autoimmunity.CD6 as a therapeutic target in autoimmune diseases: successes and challenges.Vitamin D responsive elements within the HLA-DRB1 promoter region in Sardinian multiple sclerosis associated alleles.The TCR's sensitivity to self peptide-MHC dictates the ability of naive CD8(+) T cells to respond to foreign antigens.Peripheral residence of naïve CD4 T cells induces MHC class II-dependent alterations in phenotype and function.Analysis of ancestral and functionally relevant CD5 variants in systemic lupus erythematosus patients.A role for the Tec family tyrosine kinase Txk in T cell activation and thymocyte selectionCD6 attenuates early and late signaling events, setting thresholds for T-cell activationConserved Molecular Underpinnings and Characterization of a Role for Caveolin-1 in the Tumor Microenvironment of Mature T-Cell Lymphomas.CD24 on thymic APCs regulates negative selection of myelin antigen-specific T lymphocytes.CD5-CK2 Signaling Modulates Erk Activation and Thymocyte Survival.Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands.T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase.Homeostatic competition among T cells revealed by conditional inactivation of the mouse Cd4 gene.T cell regulation as a side effect of homeostasis and competition.A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinaseSensory adaptation in naive peripheral CD4 T cells.Naïve helper T cells with high CD5 expression have increased calcium signaling.CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity.Thymocyte development is normal in CTLA-4-deficient miceT-cell modulatory properties of CD5 and its role in antitumor immune responses
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A role for CD5 in TCR-mediated signal transduction and thymocyte selection
description
article publié dans la revue scientifique Science
@fr
im Juli 1995 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Science
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в липні 1995
@uk
name
A role for CD5 in TCR-mediated signal transduction and thymocyte selection
@en
A role for CD5 in TCR-mediated signal transduction and thymocyte selection
@nl
type
label
A role for CD5 in TCR-mediated signal transduction and thymocyte selection
@en
A role for CD5 in TCR-mediated signal transduction and thymocyte selection
@nl
prefLabel
A role for CD5 in TCR-mediated signal transduction and thymocyte selection
@en
A role for CD5 in TCR-mediated signal transduction and thymocyte selection
@nl
P2093
P356
P1433
P1476
A role for CD5 in TCR-mediated signal transduction and thymocyte selection
@en
P2093
A Tarakhovsky
J A Ledbetter
S B Kanner
P304
P356
10.1126/SCIENCE.7542801
P407
P577
1995-07-01T00:00:00Z