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Capturing Biological Activity in Natural Product Fragments by Chemical SynthesisDesign, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivityTranslating Nature's Library: The Bryostatins and Function-Oriented SynthesisTotal synthesis of bryostatins: the development of methodology for the atom-economic and stereoselective synthesis of the ring C subunit.Total syntheses of bryostatins: synthesis of two ring-expanded bryostatin analogues and the development of a new-generation strategy to access the C7-C27 fragment.Atom-economic and stereoselective syntheses of the ring a and B subunits of the bryostatins.Neurotrophic natural products: chemistry and biology.Probing the biology of natural products: molecular editing by diverted total synthesis.Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase Cδ.Microbial natural products: molecular blueprints for antitumor drugs.Polyketide construction via hydrohydroxyalkylation and related alcohol C-H functionalizations: reinventing the chemistry of carbonyl addition.Toward the ideal synthesis and molecular function through synthesis-informed design.Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin.Natural product analogues: towards a blueprint for analogue-focused synthesis.Enantioselective synthesis of (-)-exiguolide by iterative stereoselective dioxinone-directed Prins cyclizations.Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV.Syntheses of C17-C27 fragments of 20-deoxybryostatins for assembly using Julia and metathesis reactions.Total Synthesis of Bryostatin 8 Using an Organosilane-Based Strategy.Total synthesis of 7-des-O-pivaloyl-7-O-benzylbryostatin 10.Synthetic approaches to the C11-C27 fragments of bryostatins.Total synthesis of a 20-deoxybryostatin.The evolution of a stereoselective synthesis of the C1-C16 fragment of bryostatins.
P2860
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P2860
description
article
@en
im September 1990 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована у вересні 1990
@uk
name
Synthesis of bryostatin 7
@en
Synthesis of bryostatin 7
@nl
type
label
Synthesis of bryostatin 7
@en
Synthesis of bryostatin 7
@nl
prefLabel
Synthesis of bryostatin 7
@en
Synthesis of bryostatin 7
@nl
P2093
P356
P1476
Synthesis of bryostatin 7
@en
P2093
David C. Whritenour
John C. Roberts
Masanori Kageyama
Michael H. Nantz
Peter Somfai
Satoru Masamune
Tadashi Tamura
P304
P356
10.1021/JA00176A058
P407
P577
1990-09-01T00:00:00Z