The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations
about
Ultrasensitivity in multisite phosphorylation of membrane-anchored proteinsCrystal structure of the 47-kDa lipoprotein of Treponema pallidum reveals a novel penicillin-binding proteinThe protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functionsSpatiotemporal patterning during T cell activation is highly diverse.The CD3 zeta subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse.T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells.PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit.Organization of proximal signal initiation at the TCR:CD3 complex.TCR signal initiation machinery is pre-assembled and activated in a subset of membrane raftsInvariant NKT cell development requires a full complement of functional CD3 zeta immunoreceptor tyrosine-based activation motifsThe cytoplasmic tail of the T cell receptor CD3 epsilon subunit contains a phospholipid-binding motif that regulates T cell functions.HIV-1 Nef: a multifaceted modulator of T cell receptor signaling.ITAMs versus ITIMs: striking a balance during cell regulation.Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity.An evolutionary and structural perspective on T cell antigen receptor function.The formation and functions of the 21- and 23-kDa tyrosine-phosphorylated TCR zeta subunits.The intrinsically disordered cytoplasmic domain of the T cell receptor zeta chain binds to the nef protein of simian immunodeficiency virus without a disorder-to-order transition.The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.The signaling adaptor protein CD3zeta is a negative regulator of dendrite development in young neuronsReductionism Is Dead: Long Live Reductionism! Systems Modeling Needs Reductionist ExperimentsMultisite Phosphorylation Modulates the T Cell Receptor ζ-Chain Potency but not the Switchlike Response.Predictive Model of Lymphocyte-Specific Protein Tyrosine Kinase (LCK) AutoregulationThe discovery of a reciprocal relationship between tyrosine-kinase signaling and cullin neddylationTransgenic expression of microRNA-181d augments the stress-sensitivity of CD4(+)CD8(+) thymocytes.The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality.Cutting Edge: CD3 ITAM Diversity Is Required for Optimal TCR Signaling and Thymocyte Development.High dose of dexamethasone upregulates TCR/CD3-induced calcium response independent of TCR zeta chain expression in human T lymphocytes.Abnormal expression of various molecular forms and distribution of T cell receptor zeta chain in patients with systemic lupus erythematosus.Investigation of the kinetics and order of tyrosine phosphorylation in the T-cell receptor zeta chain by the protein tyrosine kinase Lck.CD38 signaling in T cells is initiated within a subset of membrane rafts containing Lck and the CD3-zeta subunit of the T cell antigen receptor.Fine-Tuning of Optimal TCR Signaling in Tumor-Redirected CD8 T Cells by Distinct TCR Affinity-Mediated Mechanisms.Ectopic expression of the immune adaptor protein CD3zeta in neural stem/progenitor cells disrupts cell-fate specification.
P2860
Q24616880-B5A9EB64-3C3D-4A80-8A62-8DB72BE94155Q27639530-EFB50067-13CC-45BE-9D33-E9070A6F5D15Q28507911-F4C524EF-FBB4-4782-91F9-BA7948046710Q30488141-F0208A5D-9E28-495A-98F7-AD5EF44DD95DQ30500933-1E2C58ED-2808-41A6-B6BD-C33C53E9DEB1Q30856414-D77B78FA-58B3-4B32-A2E3-0425CF533B65Q31032344-AAE7F2FD-DD3B-45B3-85A8-F63B9DC868B6Q33753888-1BEBE784-5F17-4E30-80A0-9CCA584C6D4BQ34078807-0D7BB045-AF71-46B2-B1F8-7B81284128BEQ34162876-6744432C-E0DF-4509-84A1-D0E1893E549BQ34194355-F99C1795-BB0C-4766-A623-DE56721CBA7CQ34316824-4735711D-5B38-432C-8A0A-2E73206C8E02Q34502855-DB2E76B7-61B8-4693-BBC4-3D9A5B5B45AAQ34649554-4D6F74A5-4E0D-4444-91AB-ACDD18DA73BCQ35076666-0F97F758-F462-4509-9C96-065FF653B810Q35076675-CEC4C1D2-B073-415C-A86B-03BDF9A7D29AQ35580612-59CF568B-CB66-44FE-B844-7D14FA47823CQ35651974-02A2B56E-29B9-4A42-A5AC-9A4EC4EE8B95Q36678077-6C6035B2-F935-4220-BF58-266762D8755CQ36850190-6F536EFE-C431-4029-ACD6-EF121EA8168BQ36850200-7F01EF90-1675-4D33-809D-5F692D3120CDQ37162653-AC6911EE-90FD-4A5C-A68C-9345672D7BABQ37215710-4A73BAF8-3A8E-4B07-8627-5BEB98405A9BQ37458631-68C21B4F-C9A4-4DAD-9456-1DE6EEE17978Q38411250-5674A456-B391-4DEA-A8F7-4FE773D71D91Q38667200-1533EAD7-D407-494F-AAEC-EFC8F742EAF6Q43763327-B8BA6935-9C29-4315-AFA7-7AEB2014DFFFQ43870752-D03213D5-043A-41E8-B6E9-EECE267DD80CQ44446804-3BA3ED34-51FF-470C-8279-0C07EF6863D9Q44605241-CD1644A5-9277-4375-9BB6-BFC643B061A9Q47113506-F05BD9F7-A616-48FB-B996-9AFCCCCB8DA5Q48969830-FE3A17EB-37A8-4DF1-9EFB-19CAF15FAE42
P2860
The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations
description
im Oktober 2000 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в жовтні 2000
@uk
name
The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations
@en
The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations
@nl
type
label
The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations
@en
The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations
@nl
prefLabel
The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations
@en
The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations
@nl
P2093
P2860
P356
P1433
P1476
The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations
@en
P2093
Brett Tohlen
Carolyn R. Moomaw
Clive A. Slaughter
Nicolai S. C. van Oers
Steve Afendis
P2860
P304
P356
10.1038/79774
P407
P577
2000-10-01T00:00:00Z