about
SRT1720 improves survival and healthspan of obese miceEvidence for a common mechanism of SIRT1 regulation by allosteric activatorsDeclining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during agingSIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial functionJNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks.Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein.Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis.A conserved NAD+ binding pocket that regulates protein-protein interactions during aging.Identification of a SIRT1 mutation in a family with type 1 diabetes.Small molecule SIRT1 activators for the treatment of aging and age-related diseases.Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism.Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene.Characterization of murine SIRT3 transcript variants and corresponding protein products.Measurement of sirtuin enzyme activity using a substrate-agnostic fluorometric nicotinamide assay.Incorporation of bridged nucleic acids into CRISPR RNAs improves Cas9 endonuclease specificity.
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Basil P Hubbard
@ast
Basil P Hubbard
@en
Basil P Hubbard
@es
Basil P Hubbard
@nl
type
label
Basil P Hubbard
@ast
Basil P Hubbard
@en
Basil P Hubbard
@es
Basil P Hubbard
@nl
prefLabel
Basil P Hubbard
@ast
Basil P Hubbard
@en
Basil P Hubbard
@es
Basil P Hubbard
@nl
P106
P31
P496
0000-0003-4353-9674