Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem Cells
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Hematopoietic stem cell development, niches, and signaling pathwaysSignaling Interplay between Bone Marrow Adipose Tissue and Multiple Myeloma cellsCutting the brakes on hematopoietic regeneration by blocking TGFβ to limit chemotherapy-induced myelosuppressionEpigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical ImplicationsMegakaryocytes, malignancy and bone marrow vascular nichesStem cells, megakaryocytes, and plateletsPathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of TPO receptor agonists in aplastic anemia and myelodysplastic syndromesProstate cancer and parasitism of the bone hematopoietic stem cell nicheSTAT5 in hematopoietic stem cell biology and transplantationEltrombopag for the treatment of aplastic anemia: current perspectivesTyrosine kinase inhibitors and mesenchymal stromal cells: effects on self-renewal, commitment and functionsCommunication of bone cells with hematopoiesis, immunity and energy metabolismThe hematopoietic stem cell niche in homeostasis and diseaseCD44, Hyaluronan, the Hematopoietic Stem Cell, and Leukemia-Initiating CellsLnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammationMERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signalingBone marrow transplantation versus immunosuppressive therapy in patients with acquired severe aplastic anemia.Incomplete restoration of Mpl expression in the mpl-/- mouse produces partial correction of the stem cell-repopulating defect and paradoxical thrombocytosis.Perturbation of single hematopoietic stem cell fates in artificial nichesFlow-cytometric phosphoprotein analysis reveals agonist and temporal differences in responses of murine hematopoietic stem/progenitor cellsGene therapy of MPL deficiency: challenging balance between leukemia and pancytopenia.Congenital amegakaryocytic thrombocytopenia.Thrombopoietin and hematopoietic stem cells.Thrombopoietin receptor agonist therapy in primary immune thrombocytopenia is associated with bone marrow hypercellularity and mild reticulin fibrosis but not other stromal abnormalities.Inherited thrombocytopenias: an approach to diagnosis and management.Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling.A pilot phase I dose finding safety study of the thrombopoietin-receptor agonist, eltrombopag, in patients with myelodysplastic syndrome treated with azacitidine.Immunosuppressive therapy for transplant-ineligible aplastic anemia patients.Inhibition of Thrombopoietin/Mpl Signaling in Adult Hematopoiesis Identifies New Candidates for Hematopoietic Stem Cell Maintenance.Novel mechanisms of platelet clearance and thrombopoietin regulation.Inherited thrombocytopenias-recent advances in clinical and molecular aspects.The Thrombopoietin Receptor: Structural Basis of Traffic and Activation by Ligand, Mutations, Agonists, and Mutated Calreticulin.Gab2 promotes hematopoietic stem cell maintenance and self-renewal synergistically with STAT5The bone marrow at the crossroads of blood and immunityDynamic niches in the origination and differentiation of haematopoietic stem cells.p53 regulates hematopoietic stem cell quiescence.Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells.Human hemato-lymphoid system mice: current use and future potential for medicine.Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.
P2860
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P2860
Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem Cells
description
article
@en
im November 2007 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в грудні 2007
@uk
name
Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem Cells
@en
Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem Cells
@nl
type
label
Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem Cells
@en
Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem Cells
@nl
prefLabel
Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem Cells
@en
Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem Cells
@nl
P2093
P50
P1433
P1476
Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells
@en
P2093
Christina T Jensen
Craig D Hyland
Jennifer Antonchuk
Lina A Thoren
Marja Ekblom
Natalija Buza-Vidas
Warren S Alexander
P304
P356
10.1016/J.STEM.2007.10.008
P407
P577
2007-11-20T00:00:00Z