Intracellular Phosphotyrosine Induction by Major Histocompatibility Complex Class II Requires Co-aggregation with Membrane Rafts
about
LAP, a lymphocyte activation gene-3 (LAG-3)-associated protein that binds to a repeated EP motif in the intracellular region of LAG-3, may participate in the down-regulation of the CD3/TCR activation pathwayLipid rafts and B-cell activation.Floating the raft hypothesis for immune receptors: access to rafts controls receptor signaling and trafficking.The anti-diabetic bis(maltolato)oxovanadium(IV) decreases lipid order while increasing insulin receptor localization in membrane microdomains.Boosting immune response with the invariant chain segments via association with non-peptide binding region of major histocompatibility complex class II molecules.Role of sphingomyelinase and ceramide in modulating rafts: do biophysical properties determine biologic outcome?Cholesterol-dependent clustering of IL-2Ralpha and its colocalization with HLA and CD48 on T lymphoma cells suggest their functional association with lipid rafts.MHC Class II and CD9 in human eosinophils localize to detergent-resistant membrane microdomainsSphingolipid Organization in the Plasma Membrane and the Mechanisms That Influence ItAssociation of major histocompatibility complex II with cholesterol- and sphingolipid-rich membranes precedes peptide loading.Insulin receptors and downstream substrates associate with membrane microdomains after treatment with insulin or chromium(III) picolinate.AKAPs in lipid rafts are required for optimal antigen presentation by dendritic cells.Influence of lipid rafts on CD1d presentation by dendritic cells.Combination immunotherapy with anti-CD20 and anti-HLA-DR monoclonal antibodies induces synergistic anti-lymphoma effects in human lymphoma cell lines.Location of major histocompatibility complex class II molecules in rafts on dendritic cells enhances the efficiency of T-cell activation and proliferation.MHC II molecules and invariant chain reside in membranes distinct from conventional lipid rafts.Complex formation of CD23/surface immunoglobulin and CD23/CD81/MHC class II on an EBV-transformed human B cell line and inferable role of tetraspanin.Presentation of alpha-galactosylceramide by murine CD1d to natural killer T cells is facilitated by plasma membrane glycolipid rafts.Delineation of the HLA-DR region and the residues involved in the association with the cytoskeleton.Lipid raft-dependent and -independent signaling through HLA-DR molecules.MHC class II signaling function is regulated during maturation of plasmacytoid dendritic cells.Lipid-mediated presentation of MHC class II molecules guides thymocytes to the CD4 lineage.Dissociation of caspase-mediated events and programmed cell death induced via HLA-DR in follicular lymphoma.Milk-Derived GM3 and GD3 Differentially Inhibit Dendritic Cell Maturation and Effector FunctionalitiesFeeding long-chain n-3 polyunsaturated fatty acids to obese leptin receptor-deficient JCR:LA-cp rats modifies immune function and lipid-raft fatty acid composition
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P2860
Intracellular Phosphotyrosine Induction by Major Histocompatibility Complex Class II Requires Co-aggregation with Membrane Rafts
description
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
im August 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в серпні 1999
@uk
name
Intracellular Phosphotyrosine ...... ggregation with Membrane Rafts
@en
Intracellular Phosphotyrosine ...... ggregation with Membrane Rafts
@nl
type
label
Intracellular Phosphotyrosine ...... ggregation with Membrane Rafts
@en
Intracellular Phosphotyrosine ...... ggregation with Membrane Rafts
@nl
prefLabel
Intracellular Phosphotyrosine ...... ggregation with Membrane Rafts
@en
Intracellular Phosphotyrosine ...... ggregation with Membrane Rafts
@nl
P2093
P2860
P356
P1476
Intracellular phosphotyrosine ...... ggregation with membrane rafts
@en
P2093
P2860
P304
22591-22596
P356
10.1074/JBC.274.32.22591
P407
P577
1999-08-01T00:00:00Z