about
Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres.CRISPR-Cas9: A Revolutionary Tool for Cancer ModellingCyclin E gene (CCNE) amplification and hCDC4 mutations in endometrial carcinomaMolecular study of a new family with hereditary renal cell carcinoma and a translocation t(3;8)(p13;q24.1).Abrogation of RUNX1 gene expression in de novo myelodysplastic syndrome with t(4;21)(q21;q22).Efficient Recreation of t(11;22) EWSR1-FLI1+ in Human Stem Cells Using CRISPR/Cas9.Generation and characterization of a human iPSC cell line expressing inducible Cas9 in the "safe harbor" AAVS1 locusDistinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations.A mutation in the POT1 gene is responsible for cardiac angiosarcoma in TP53-negative Li-Fraumeni-like families.Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency.Cloning of a new familial t(3;8) translocation associated with conventional renal cell carcinoma reveals a 5 kb microdeletion and no gene involved in the rearrangement.CRISPR-Cas9 technology: applications and human disease modelling.Downregulation of specific miRNAs in hyperdiploid multiple myeloma mimics the oncogenic effect of IgH translocations occurring in the non-hyperdiploid subtype.Chromosomal instability and phenotypic plasticity during the squamous-spindle carcinoma transition: association of a specific T(14;15) with malignant progression.Molecular cytogenetic characterization of rhabdomyosarcoma cell lines.Truncated RUNX1 protein generated by a novel t(1;21)(p32;q22) chromosomal translocation impairs the proliferation and differentiation of human hematopoietic progenitors.Engineering human tumour-associated chromosomal translocations with the RNA-guided CRISPR-Cas9 system.Cytogenetic characterization reveals that the SAM-1 erythroid cell line is derived from K-562 cells.Genetic unmasking of epigenetically silenced tumor suppressor genes in colon cancer cells deficient in DNA methyltransferases.Cyclin D1 gene (CCND1) mutations in endometrial cancer.Immunohistochemical characteristics defined by tissue microarray of hereditary breast cancer not attributable to BRCA1 or BRCA2 mutations: differences from breast carcinomas arising in BRCA1 and BRCA2 mutation carriers.Therapeutic gene editing in CD34+ hematopoietic progenitors from Fanconi anemia patients.About the origin and development of hereditary conventional renal cell carcinoma in a four-generation t(3;8)(p14.1;q24.23) family.mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis.CRISPR/Cas9 Technology: Applications and Human Disease Modeling.Differential gene expression profile in endometrioid and nonendometrioid endometrial carcinoma: STK15 is frequently overexpressed and amplified in nonendometrioid carcinomas.Molecular alterations associated with cyclin D1 overexpression in endometrial cancer.Germline mutations in the spindle assembly checkpoint genes BUB1 and BUB3 are infrequent in familial colorectal cancer and polyposis.Modeling mixed-lineage-rearranged leukemia initiation in CD34+ cells: a "CRISPR" solution.Chromatin modifications induced by the AML1-ETO fusion protein reversibly silence its genomic targets through AML1 and Sp1 binding motifs.MLL gene fusions in human leukaemias: in vivo modelling to recapitulate these primary tumourigenic events.Epithelioid sarcoma with SYT-SSX1 fusion gene expression: molecular and cytogenetic analysis.A novel candidate region linked to development of both pheochromocytoma and head/neck paraganglioma
P50
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P50
description
onderzoeker
@nl
researcher ORCID id 0000-0001-7221-3636
@en
name
Sandra Rodriguez-Perales
@ast
Sandra Rodriguez-Perales
@en
Sandra Rodriguez-Perales
@es
Sandra Rodriguez-Perales
@nl
type
label
Sandra Rodriguez-Perales
@ast
Sandra Rodriguez-Perales
@en
Sandra Rodriguez-Perales
@es
Sandra Rodriguez-Perales
@nl
prefLabel
Sandra Rodriguez-Perales
@ast
Sandra Rodriguez-Perales
@en
Sandra Rodriguez-Perales
@es
Sandra Rodriguez-Perales
@nl
P106
P21
P31
P496
0000-0001-7221-3636