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Determinants of Cytochrome P450 2C8 Substrate Binding: STRUCTURES OF COMPLEXES WITH MONTELUKAST, TROGLITAZONE, FELODIPINE, AND 9-CIS-RETINOIC ACIDHuman anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drugOxidative metabolism of ferrocene analogues of tamoxifen: characterization and antiproliferative activities of the metabolites.Unusual regioselectivity and active site topology of human cytochrome P450 2J2Dehydrogenation of the indoline-containing drug 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (indapamide) by CYP3A4: correlation with in silico predictionsAntigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera.Selective, competitive and mechanism-based inhibitors of human cytochrome P450 2J2.Induction of drug metabolizing enzymes in the liver of diabetic mice.Membrane fluidity and drug metabolism in liver microsomes of lean, ob/ob and db/db mice.Ferrocenyl quinone methides as strong antiproliferative agents: formation by metabolic and chemical oxidation of ferrocenyl phenols.Bioactivation of clopidogrel and prasugrel: factors determining the stereochemistry of the thiol metabolite double bond.Inhibitory Effects of Trapping Agents of Sulfur Drug Reactive Intermediates against Major Human Cytochrome P450 Isoforms.Cytochromes P450 catalyze both steps of the major pathway of clopidogrel bioactivation, whereas paraoxonase catalyzes the formation of a minor thiol metabolite isomer.The shikimate pathway. I. Preparation of 3-3H, 4-3H and 2,4-3H2 D-shikimic acid.Indirect cytotoxicity of flucloxacillin toward human biliary epithelium via metabolite formation in hepatocytes.Synthesis of sulfaphenazole derivatives and their use as inhibitors and tools for comparing the active sites of human liver cytochromes P450 of the 2C subfamily.Sulfaphenazole derivatives as tools for comparing cytochrome P450 2C5 and human cytochromes P450 2Cs: identification of a new high affinity substrate common to those enzymes.Oxidative activation of the thiophene ring by hepatic enzymes. Hydroxylation and formation of electrophilic metabolites during metabolism of tienilic acid and its isomer by rat liver microsomes.In vitro metabolism of isaxonine phosphate: formation of two metabolites, 5-hydroxyisaxonine and 2-aminopyrimidine, and covalent binding to microsomal proteins.The end product of transglutaminase crosslinking: simultaneous quantitation of [Nepsilon-(gamma-glutamyl) lysine] and lysine by HPLC-MS3.First evidence that cytochrome P450 may catalyze both S-oxidation and epoxidation of thiophene derivatives.Automated multiple analysis of protein structures: application to homology modeling of cytochromes P450.A new generation of ferrociphenols leads to a great diversity of reactive metabolites, and exhibits remarkable antiproliferative properties.Metabolic Activation of Prasugrel: Nature of the Two Competitive Pathways Resulting in the Opening of Its Thiophene RingRole of Arginine 117 in Substrate Recognition by Human Cytochrome P450 2J2Evaluation of Deuterium Labeled and Unlabeled Bis-methyl Glutathione Combined with Nanoliquid Chromatography−Mass Spectrometry to Screen and Characterize Reactive Drug MetabolitesComparison of the Substrate Specificities of Human Liver Cytochrome P450s 2C9 and 2C18: Application to the Design of a Specific Substrate of CYP 2C18Diclofenac and Its Derivatives As Tools for Studying Human Cytochromes P450 Active Sites: Particular Efficiency and Regioselectivity of P450 2CsOpposite Behaviors of Reactive Metabolites of Tienilic Acid and Its Isomer toward Liver Proteins: Use of Specific Anti-Tienilic Acid−Protein Adduct Antibodies and the Possible Relationship with Different Hepatotoxic Effects of the Two CompoundsThe Substrate Binding Site of Human Liver Cytochrome P450 2C9: An NMR Study†Human Anti-Mitochondria Autoantibodies Appearing in Iproniazid-Induced Immunoallergic Hepatitis Recognize Human Liver Monoamine Oxidase BOxidation of Tienilic Acid by Human Yeast-Expressed Cytochromes P-450 2C8, 2C9, 2C18 and 2C19. Evidence that this Drug is A Mechanism-Based Inhibitor Specific for Cytochrome P-450 2C9The Substrate Binding Site of Human Liver Cytochrome P450 2C9: An Approach Using Designed Tienilic Acid Derivatives and Molecular ModelingHydroxylation of the thiophene ring by hepatic monooxygenasesMetabolic hydroxylation of the thiophene ring: Isolation of 5-hydroxy-tienilic acid as the major urinary metabolite of tienilic acid in man and ratEndogenous induction of epoxide hydrolase, benzo(a)pyrene hydroxylase and glutathione-S-transferase in “responsive” C57B16 mice and in “nonresponsive” DBA2 mice during pregnancyMetabolism of benzo[a]pyrene by brain microsomes of fetal and adult rats and mice. Induction by 5,6 benzoflavone, comparison with liver and lung microsomal activitiesPresence of benzo[a]pyrene metabolizing activities in isolated rat liver nucleoliUPD-glucuronosyltransferase, epoxide hydrolase and gultathione S-transferaseEffect of purified epoxide hydrolase on metabolic activa-tion and binding of benzo(a)pyrene to exogenous DNA. Shift of the activation pathway
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P50
description
Forscher
@de
chercheur
@fr
investigador
@es
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
研究者
@zh
name
Patrick Dansette
@ast
Patrick Dansette
@en
Patrick Dansette
@es
Patrick Dansette
@nl
type
label
Patrick Dansette
@ast
Patrick Dansette
@en
Patrick Dansette
@es
Patrick Dansette
@nl
altLabel
Patrick M. Dansette
@en
Philip Dansette ( an error in one paper with Bresnick)
@en
prefLabel
Patrick Dansette
@ast
Patrick Dansette
@en
Patrick Dansette
@es
Patrick Dansette
@nl
P1053
B-8384-2014
P106
P31
P3829
P3835
patrick-dansette2
P496
0000-0002-3694-3348