Calcium-Dependent Src Phosphorylation and Reactive Oxygen Species Generation Are Implicated in the Activation of Human Platelet Induced by Thromboxane A2 Analogs

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Calcium-Dependent Src Phosphorylation and Reactive Oxygen Species Generation Are Implicated in the Activation of Human Platelet Induced by Thromboxane A2 Analogs

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im Januar 2018 veröffentlichter wissenschaftlicher Artikel

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wetenschappelijk artikel

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наукова стаття, опублікована у 2018

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name

Calcium-Dependent Src Phosphor ...... uced by Thromboxane A2 Analogs

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Calcium-Dependent Src Phosphor ...... uced by Thromboxane A2 Analogs

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Calcium-Dependent Src Phosphor ...... uced by Thromboxane A2 Analogs

@en

Calcium-Dependent Src Phosphor ...... uced by Thromboxane A2 Analogs

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Calcium-Dependent Src Phosphor ...... uced by Thromboxane A2 Analogs

@en

Calcium-Dependent Src Phosphor ...... uced by Thromboxane A2 Analogs

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P1476

Calcium-Dependent Src Phosphor ...... uced by Thromboxane A2 Analogs

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P2093

Alessandra Meneguzzi

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Dino Veneri

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Giorgio Berton

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Laura Fumagalli

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Marco Ricci

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Maurizio Degan

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Pietro Minuz

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Roberta Ferraro

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Stefano Calabria

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P2860

G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets

A new generation of Ca2+ indicators with greatly improved fluorescence properties

Differential requirements for calcium and Src family kinases in platelet GPIIb/IIIa activation and thromboxane generation downstream of different G-protein pathways

Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets

An important role of the SRC family kinase Lyn in stimulating platelet granule secretion

The thromboxane A2 receptor activates mitogen-activated protein kinase via protein kinase C-dependent Gi coupling and Src-dependent phosphorylation of the epidermal growth factor receptor.

Platelet shape change is mediated by both calcium-dependent and -independent signaling pathways. Role of p160 Rho-associated coiled-coil-containing protein kinase in platelet shape change.

The new tyrosine-kinase inhibitor and anticancer drug dasatinib reversibly affects platelet activation in vitro and in vivo.

G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling

G(12/13) signaling pathways substitute for integrin αIIbβ3-signaling for thromboxane generation in platelets.

P304

1081

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P31

scholarly article

P356

10.3389/FPHAR.2018.01081

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P407

English

P478

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P577

2018-01-01T00:00:00Z

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P698

30319416

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P921

Farmakologi

phosphorylation

P932

6169403

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