G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling - Wikidata - awgldk - TriplyDB

G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling

G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling

http://www.wikidata.org/entity/Q33743722

about

Integrin and GPCR Crosstalk in the Regulation of ASM Contraction Signaling in Asthma PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12 The actin-bundling protein L-plastin supports T-cell motility and activation Turning receptors on and off with intracellular pepducins: new insights into G-protein-coupled receptor drug development RhoC interacts with integrin α5β1 and enhances its trafficking in migrating pancreatic carcinoma cells Solute carrier family 3 member 2 (Slc3a2) controls yolk syncytial layer (YSL) formation by regulating microtubule networks in the zebrafish embryo.A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo.A directional switch of integrin signalling and a new anti-thrombotic strategy.Targeting integrin and integrin signaling in treating thrombosis.Platelets and infection - an emerging role of platelets in viral infection.Pro32Pro33 mutations in the integrin β3 PSI domain result in αIIbβ3 priming and enhanced adhesion: reversal of the hypercoagulability phenotype by the Src inhibitor SKI-606.Pannexin- and Connexin-Mediated Intercellular Communication in Platelet Function.The zinc-binding region of IL-2 inducible T cell kinase (Itk) is required for interaction with Gα13 and activation of serum response factor G(12/13) signaling pathways substitute for integrin αIIbβ3-signaling for thromboxane generation in platelets.Heterotrimeric G protein signaling outside the realm of seven transmembrane domain receptors CB₁ cannabinoid receptors promote maximal FAK catalytic activity by stimulating cooperative signaling between receptor tyrosine kinases and integrins in neuronal cells.Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism.Gap junctions and connexin hemichannels underpin hemostasis and thrombosis.Paired immunoglobulin-like receptor B regulates platelet activation.Integrin αIIb-mediated PI3K/Akt activation in platelets.Heterotrimeric G-protein alpha-12 (Gα12) subunit promotes oral cancer metastasis.Signaling during platelet adhesion and activation Conformational changes in talin on binding to anionic phospholipid membranes facilitate signaling by integrin transmembrane helices Negative regulation of Gq-mediated pathways in platelets by G(12/13) pathways through Fyn kinase.Multiscale simulations suggest a mechanism for integrin inside-out activation.Historical perspective and future directions in platelet research.An important role for Akt3 in platelet activation and thrombosis Integrin-αvβ3 regulates thrombopoietin-mediated maintenance of hematopoietic stem cells.Gastrin-stimulated Gα13 Activation of Rgnef Protein (ArhGEF28) in DLD-1 Colon Carcinoma Cells.JAM-A protects from thrombosis by suppressing integrin αIIbβ3-dependent outside-in signaling in platelets.Chronic baclofen desensitizes GABA(B)-mediated G-protein activation and stimulates phosphorylation of kinases in mesocorticolimbic rat brain.MicroRNA Mediated Chemokine Responses in Human Airway Smooth Muscle Cells.Platelets Proteomic Profiles of Acute Ischemic Stroke Patients.Integrins activate trimeric G proteins via the nonreceptor protein GIV/Girdin Gα13 Switch Region 2 Binds to the Talin Head Domain and Activates αIIbβ3 Integrin in Human Platelets.RhoA and Rac1 GTPases Differentially Regulate Agonist-Receptor Mediated Reactive Oxygen Species Generation in Platelets The interaction of Gα13 with integrin β1 mediates cell migration by dynamic regulation of RhoA Focal adhesions are foci for tyrosine-based signal transduction via GIV/Girdin and G proteins.Characterization of a Novel Integrin Binding Protein, VPS33B, Which Is Important for Platelet Activation and In Vivo Thrombosis and Hemostasis.

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P2860

G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling

http://www.wikidata.org/entity/Q33743722

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

G protein subunit Galpha13 bin ...... ntegrin "outside-in" signaling

@ast

G protein subunit Galpha13 bin ...... ntegrin "outside-in" signaling

@en

type

label

G protein subunit Galpha13 bin ...... ntegrin "outside-in" signaling

@ast

G protein subunit Galpha13 bin ...... ntegrin "outside-in" signaling

@en

prefLabel

G protein subunit Galpha13 bin ...... ntegrin "outside-in" signaling

@ast

G protein subunit Galpha13 bin ...... ntegrin "outside-in" signaling

@en

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SCIENCE.1174779

P1433

P1476

G protein subunit Galpha13 bin ...... ntegrin "outside-in" signaling

@en

P2093

Bo Shen

http://www.w3.org/2001/XMLSchema#string

Christina Chow

http://www.w3.org/2001/XMLSchema#string

Haixia Gong

http://www.w3.org/2001/XMLSchema#string

Panagiotis Flevaris

http://www.w3.org/2001/XMLSchema#string

Stephen C-T Lam

http://www.w3.org/2001/XMLSchema#string

Tatyana A Voyno-Yasenetskaya

http://www.w3.org/2001/XMLSchema#string

Tohru Kozasa

http://www.w3.org/2001/XMLSchema#string

Xiaoping Du

http://www.w3.org/2001/XMLSchema#string

P2860

Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton

Src kinase activation by direct interaction with the integrin beta cytoplasmic domain

Integrins: bidirectional, allosteric signaling machines

Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3

Platelet integrin alpha(IIb)beta(3): activation mechanisms

p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13

Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13

G13 is an essential mediator of platelet activation in hemostasis and thrombosis

Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets

Integrin signalling in directed cell migration.

P304

340-343

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P31

scholarly article

P356

10.1126/SCIENCE.1174779

http://www.w3.org/2001/XMLSchema#string

P407

P433

5963

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P478

327

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P577

2010-01-01T00:00:00Z

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41028280

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20075254

http://www.w3.org/2001/XMLSchema#string

P932

2842917

http://www.w3.org/2001/XMLSchema#string