about
Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and LeukemiaTransient responses to NOTCH and TLX1/HOX11 inhibition in T-cell acute lymphoblastic leukemia/lymphomaWhole-genome sequencing identifies recurrent somatic NOTCH2 mutations in splenic marginal zone lymphoma.Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.Cancer genetics: activated notch takes center stage in T-cell leukemogenesis.Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cellsNOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species.Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A.Oncogenic Notch signaling in T-cell and B-cell lymphoproliferative disorders.Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia.High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia.Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development
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description
researcher ORCID ID = 0000-0003-2099-0956
@en
wetenschapper
@nl
name
Mark Chiang
@ast
Mark Chiang
@en
Mark Chiang
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Mark Chiang
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type
label
Mark Chiang
@ast
Mark Chiang
@en
Mark Chiang
@es
Mark Chiang
@nl
prefLabel
Mark Chiang
@ast
Mark Chiang
@en
Mark Chiang
@es
Mark Chiang
@nl
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P1153
8901476700
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0000-0003-2099-0956