NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species.
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Targeting leukemia stem cells: which pathways drive self-renewal activity in T-cell acute lymphoblastic leukemia?Targeting Notch to overcome radiation resistanceThe relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemiaProteasome inhibitors exert cytotoxicity and increase chemosensitivity via transcriptional repression of Notch1 in T-cell acute lymphoblastic leukemiaLoss of Notch1-dependent p21(Waf1/Cip1) expression influences the Notch1 outcome in tumorigenesis.Chromatinized protein kinase C-θ directly regulates inducible genes in epithelial to mesenchymal transition and breast cancer stem cellsDistinct isoform of FABP7 revealed by screening for retroelement-activated genes in diffuse large B-cell lymphoma.SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cellsGlobal differential expression of genes located in the Down Syndrome Critical Region in normal human brain.Leukemia stem cells in T-ALL require active Hif1α and Wnt signalingIGF1R Derived PI3K/AKT Signaling Maintains Growth in a Subset of Human T-Cell Acute Lymphoblastic Leukemias.Identification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemiaCDK6-mediated repression of CD25 is required for induction and maintenance of Notch1-induced T-cell acute lymphoblastic leukemia.Mitochondria as oxidative signaling organelles in T-cell activation: physiological role and pathological implications.Posttranslational modifications of RUNX1 as potential anticancer targets.Loss of RUNX3 increases osteopontin expression and promotes cell migration in gastric cancer.Microenvironmental cues for T-cell acute lymphoblastic leukemia development.A novel drug "copper acetylacetonate" loaded in folic acid-tagged chitosan nanoparticle for efficient cancer cell targeting.Collaborating Pathways that Functionally Amplify NOTCH1 Signals in T-Cell Acute Lymphoblastic Leukemia.Differential expression of Notch1 intracellular domain and p21 proteins, and their clinical significance in gastric cancer.Chronic exposure to IFNα drives medullar lymphopoiesis towards T-cell differentiation in mice.The deregulated expression of miR-125b in acute myeloid leukemia is dependent on the transcription factor C/EBPα.RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia.Pluripotency transcription factors and Metabolic reprogramming of mitochondria in tumor-initiating stem-like cells.Leukemia reconstitution in vivo is driven by cells in early cell cycle and low metabolic state.Detection of microvesicle miRNA expression in ALL subtypes and analysis of their functional roles.Protein kinase Cθ: the pleiotropic T-cell signalling intermediate.The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia modelSTAT5 is essential for IL-7-mediated viability, growth, and proliferation of T-cell acute lymphoblastic leukemia cellsInvestigating chemoresistance to improve sensitivity of childhood T-cell acute lymphoblastic leukemia to parthenolide
P2860
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P2860
NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 21 October 2012
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
NOTCH1 promotes T cell leukemi ...... θ and reactive oxygen species.
@en
NOTCH1 promotes T cell leukemi ...... θ and reactive oxygen species.
@nl
type
label
NOTCH1 promotes T cell leukemi ...... θ and reactive oxygen species.
@en
NOTCH1 promotes T cell leukemi ...... θ and reactive oxygen species.
@nl
prefLabel
NOTCH1 promotes T cell leukemi ...... θ and reactive oxygen species.
@en
NOTCH1 promotes T cell leukemi ...... θ and reactive oxygen species.
@nl
P2093
P2860
P356
P1433
P1476
NOTCH1 promotes T cell leukemi ...... -θ and reactive oxygen species
@en
P2093
Andrew P Weng
Christopher R Jenkins
Connie Eaves
Hongfang Wang
Jon C Aster
Oksana Nemirovsky
Olena O Shevchuk
Sam Gusscott
Sonya H Lam
P2860
P2888
P304
P356
10.1038/NM.2960
P407
P577
2012-10-21T00:00:00Z