Loss of Ubiquitin-Binding Associated With Paget's Disease of Bone p62 (SQSTM1) Mutations
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Segregation of a M404V mutation of the p62/sequestosome 1 (p62/SQSTM1) gene with polyostotic Paget's disease of bone in an Italian family.Ubiquitin recognition by the ubiquitin-associated domain of p62 involves a novel conformational switchSelective autophagy mediated by autophagic adapter proteinsBcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitroNeighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activityCoupling of HIV-1 Antigen to the Selective Autophagy Receptor SQSTM1/p62 Promotes T-Cell-Mediated ImmunityBoning up on autophagy: the role of autophagy in skeletal biologyUbiquitin and ubiquitin-like proteins as multifunctional signalsPaget disease of bone-associated UBA domain mutations of SQSTM1 exert distinct effects on protein structure and functionUbiquitin-mediated signalling and Paget's disease of bone.Alternative splicing in osteoclasts and Paget's disease of bone.The sequestosome 1/p62 attenuates cytokine gene expression in activated macrophages by inhibiting IFN regulatory factor 8 and TNF receptor-associated factor 6/NF-kappaB activity.Ubiquitination and selective autophagyPaget's Disease of Bone among Various Ethnic Groups.p62 ubiquitin binding-associated domain mediated the receptor activator of nuclear factor-kappaB ligand-induced osteoclast formation: a new insight into the pathogenesis of Paget's disease of bone.Mutation of the sequestosome 1 (p62) gene increases osteoclastogenesis but does not induce Paget disease.Parkin represses 6-hydroxydopamine-induced apoptosis via stabilizing scaffold protein p62 in PC12 cells.Transcriptomic analysis of the autophagy machinery in crustaceansMechanisms of disease: genetics of Paget's disease of bone and related disorders.Polyubiquitin chains: functions, structures, and mechanisms.Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD.Gene expression profile in osteoclasts from patients with Paget's disease of bone.The p62 P392L mutation linked to Paget's disease induces activation of human osteoclasts.Clinical and Genetic Advances in Paget's Disease of Bone: a Review.Structural insights into specificity and diversity in mechanisms of ubiquitin recognition by ubiquitin-binding domains.Paget's disease of bone: clinical review and update.Republished: Paget's disease of bone: clinical review and update.Bcl-2 Decreases the Affinity of SQSTM1/p62 to Poly-Ubiquitin Chains and Suppresses the Aggregation of Misfolded Protein in Neurodegenerative Disease.A nonsynonymous TNFRSF11A variation increases NFκB activity and the severity of Paget's disease.SQSTM1 splice site mutation in distal myopathy with rimmed vacuoles.Molecular mechanisms of OLIG2 transcription factor in brain cancer.Mutant p62/SQSTM1 UBA domains linked to Paget's disease of bone differ in their abilities to function as stabilization signals.Dimerization of doublesex is mediated by a cryptic ubiquitin-associated domain fold: implications for sex-specific gene regulation.p62/sequestosome 1 deficiency accelerates osteoclastogenesis in vitro and leads to Paget's disease-like bone phenotypes in mice.
P2860
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P2860
Loss of Ubiquitin-Binding Associated With Paget's Disease of Bone p62 (SQSTM1) Mutations
description
article
@en
im Dezember 2004 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в грудні 2004
@uk
name
Loss of Ubiquitin-Binding Associated With Paget's Disease of Bone p62 (SQSTM1) Mutations
@en
Loss of Ubiquitin-Binding Associated With Paget's Disease of Bone p62
@nl
type
label
Loss of Ubiquitin-Binding Associated With Paget's Disease of Bone p62 (SQSTM1) Mutations
@en
Loss of Ubiquitin-Binding Associated With Paget's Disease of Bone p62
@nl
prefLabel
Loss of Ubiquitin-Binding Associated With Paget's Disease of Bone p62 (SQSTM1) Mutations
@en
Loss of Ubiquitin-Binding Associated With Paget's Disease of Bone p62
@nl
P50
P356
P1476
Loss of Ubiquitin-Binding Associated With Paget's Disease of Bone p62 (SQSTM1) Mutations
@en
P2093
Paul W Sheppard
Stuart H Ralston
P304
P356
10.1359/JBMR.041205
P577
2004-12-06T00:00:00Z