about
Human P-glycoprotein contains a greasy ball-and-socket joint at the second transmission interface.Identification of the distance between the homologous halves of P-glycoprotein that triggers the high/low ATPase activity switch.The Transmission Interfaces Contribute Asymmetrically to the Assembly and Activity of Human P-glycoproteinTariquidar inhibits P-glycoprotein drug efflux but activates ATPase activity by blocking transition to an open conformation.Cysteines introduced into extracellular loops 1 and 4 of human P-glycoprotein that are close only in the open conformation spontaneously form a disulfide bond that inhibits drug efflux and ATPase activity.A salt bridge in intracellular loop 2 is essential for folding of human p-glycoprotein.Locking intracellular helices 2 and 3 together inactivates human P-glycoprotein.Drug rescue distinguishes between different structural models of human P-glycoproteinMapping the Binding Site of the Inhibitor Tariquidar That Stabilizes the First Transmembrane Domain of P-glycoprotein.Corrector VX-809 stabilizes the first transmembrane domain of CFTR.The cystic fibrosis V232D mutation inhibits CFTR maturation by disrupting a hydrophobic pocket rather than formation of aberrant interhelical hydrogen bonds.P-glycoprotein ATPase activity requires lipids to activate a switch at the first transmission interface.Chalcogenopyrylium Compounds as Modulators of the ATP-Binding Cassette Transporters P-Glycoprotein (P-gp/ABCB1) and Multidrug Resistance Protein 1 (MRP1/ABCC1)
P50
Q37012424-5F413CEF-F9B0-4ECA-979A-E3235B20BE9EQ37653308-9EF09DCC-7EF2-48CE-ACE4-8AE977744545Q38873295-D0244EA3-0BA1-42BB-A610-CA04F821B7AAQ38933973-C9845045-3C7B-41BF-AA22-A79E6F249738Q38972586-5713BB3D-5C7F-426E-A1C4-37C153FC3BEFQ40790212-9BD3D061-83CB-4BCC-A456-0FEAFCC88BF4Q41848364-715194F1-0A84-403D-8BF0-71EE1A48CCE5Q42681206-D541441D-BA5B-4D83-AA42-2BA617717CA3Q43099273-A93DCF33-C05D-4B7E-A54A-88C1645B0955Q44348057-BB455A2F-9FF6-48D4-9DC2-340FF3374DBBQ52646788-DF03B970-AB05-4DC1-8306-22CDBEE6E430Q53156653-D0478E15-1A62-4E50-8EF6-E2DB85E966DFQ57976867-E12155B0-12A8-402F-B0A5-2CC30312C1B8
P50
description
researcher ORCID ID = 0000-0003-4335-7184
@en
wetenschapper
@nl
name
David M. Clarke
@ast
David M. Clarke
@en
David M. Clarke
@es
David M. Clarke
@nl
type
label
David M. Clarke
@ast
David M. Clarke
@en
David M. Clarke
@es
David M. Clarke
@nl
prefLabel
David M. Clarke
@ast
David M. Clarke
@en
David M. Clarke
@es
David M. Clarke
@nl
P106
P1153
7403502816
P21
P31
P496
0000-0003-4335-7184