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Inactivation of the HIF-1α/PDK3 signaling axis drives melanoma toward mitochondrial oxidative metabolism and potentiates the therapeutic activity of pro-oxidantsIntegration of Mitochondrial Targeting for Molecular Cancer TherapeuticsFarnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cellsMitochondrial electron transport is the cellular target of the oncology drug elesclomolCaspase inhibition prevents cardiac dysfunction and heart apoptosis in a rat model of sepsis.Targeting chelatable iron as a therapeutic modality in Parkinson's disease.Exploiting mitochondrial dysfunction for effective elimination of imatinib-resistant leukemic cells.Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.Mitochondrial control of nuclear apoptosis.Increased CD271 expression by the NF-kB pathway promotes melanoma cell survival and drives acquired resistance to BRAF inhibitor vemurafenib.Cigarette smoke alters the ability of human dendritic cells to promote anti-Streptococcus pneumoniae Th17 response.Mitochondrial oxidative stress is the Achille's heel of melanoma cells resistant to Braf-mutant inhibitor.Another facet to the anticancer response to lamellarin D: induction of cellular senescence through inhibition of topoisomerase I and intracellular Ros productionMetabolic features of melanoma: a gold mine of new therapeutic targets?GILZ overexpression attenuates endoplasmic reticulum stress-mediated cell death via the activation of mitochondrial oxidative phosphorylation.Metabolic rewiring in cancer cells overexpressing the glucocorticoid-induced leucine zipper protein (GILZ): Activation of mitochondrial oxidative phosphorylation and sensitization to oxidative cell death induced by mitochondrial targeted drugs.Regulation by survivin of cancer cell death induced by F14512, a polyamine-containing inhibitor of DNA topoisomerase II.The presence of apoptotic bone marrow cells impairs the efficacy of cardiac cell therapy.Inhibition of mitochondrial respiration mediates apoptosis induced by the anti-tumoral alkaloid lamellarin D.Essential role of mitochondria in apoptosis of cancer cells induced by the marine alkaloid Lamellarin D.Cancer cell mitochondria are direct proapoptotic targets for the marine antitumor drug lamellarin D.Role of endoplasmic reticulum calcium content in prostate cancer cell growth regulation by IGF and TNFalpha.Apoptosis-inducing factor determines the chemoresistance of non-small-cell lung carcinomas.Mitochondrial proliferation during apoptosis induced by anticancer agents: effects of doxorubicin and mitoxantrone on cancer and cardiac cells.Defective caspase-3 relocalization in non-small cell lung carcinoma.Apoptosis-related mitochondrial dysfunction defines human monocyte-derived dendritic cells with impaired immuno-stimulatory capacities.Influence of heat stress on human monocyte-derived dendritic cell functions with immunotherapeutic potential for antitumor vaccines.Stabilization of mitochondrial membrane potential prevents doxorubicin-induced cardiotoxicity in isolated rat heart.Terminal differentiation of human epidermal keratinocytes involves mitochondria- and caspase-dependent cell death pathway.Mitochondrial dysfunction is an essential step for killing of non-small cell lung carcinomas resistant to conventional treatment.Protective effects of cyclosporin A from endotoxin-induced myocardial dysfunction and apoptosis in rats.The novel retinoid AHPN/CD437 induces a rapid but incomplete apoptotic response in human myeloma cells.Endotoxin-induced myocardial dysfunction: evidence for a role of sphingosine production.Apoptosis inhibition in P. aeruginosa-induced lung injury influences lung fluid balance.Staining of human sperm with fluorochrome-labeled inhibitor of caspases to detect activated caspases: correlation with apoptosis and sperm parameters.Comparison of four fluorochromes for the detection of the inner mitochondrial membrane potential in human spermatozoa and their correlation with sperm motility.Expression of apoptosis regulatory factors during myocardial dysfunction in endotoxemic rats.Patient-derived tumor xenograft model to guide the use of BRAF inhibitors in metastatic melanoma.Induction of apoptosis-like mitochondrial impairment triggers antioxidant and Bcl-2-dependent keratinocyte differentiation.PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection.
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P50
description
researcher ORCID ID = 0000-0002-4663-6800
@en
wetenschapper
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name
Philippe Marchetti
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Philippe Marchetti
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Philippe Marchetti
@es
Philippe Marchetti
@nl
type
label
Philippe Marchetti
@ast
Philippe Marchetti
@en
Philippe Marchetti
@es
Philippe Marchetti
@nl
prefLabel
Philippe Marchetti
@ast
Philippe Marchetti
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Philippe Marchetti
@es
Philippe Marchetti
@nl
P106
P1153
7103205246
P21
P31
P496
0000-0002-4663-6800