about
Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's diseaseRetromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulationReversal of long-term dendritic spine alterations in Alzheimer disease modelsBehavioral assays with mouse models of Alzheimer's disease: practical considerations and guidelines.SUMO1 Affects Synaptic Function, Spine Density and MemoryDevelopment of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic DysfunctionSynaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndromeLoss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficitsFoxO1 target Gpr17 activates AgRP neurons to regulate food intakeLearning and memory and synaptic plasticity are impaired in a mouse model of Rett syndromeBDNF-mediated neurotransmission relies upon a myosin VI motor complexalpha-Synuclein produces a long-lasting increase in neurotransmitter releaseRole of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunctionAlzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficitsAlpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKIIPicomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus.Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicityMicroglial receptor for advanced glycation end product-dependent signal pathway drives beta-amyloid-induced synaptic depression and long-term depression impairment in entorhinal cortex.Endocannabinoid system: emerging role from neurodevelopment to neurodegeneration.Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia.Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits.APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutantSmall molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment.Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer's disease.Familial autoimmune myasthenia gravis with different pathogenetic antibodiesGlut4 expression defines an insulin-sensitive hypothalamic neuronal populationRAGE inhibition in microglia prevents ischemia-dependent synaptic dysfunction in an amyloid-enriched environmentPicomolar amyloid-β peptides enhance spontaneous astrocyte calcium transientsNeurotrophins, synaptic plasticity and dementia.The ARMS/Kidins220 scaffold protein modulates synaptic transmission.Notoginsenoside R1 increases neuronal excitability and ameliorates synaptic and memory dysfunction following amyloid elevation.Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signalingDesign and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy.Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosisDanish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficitsThe ankyrin repeat-rich membrane spanning (ARMS)/Kidins220 scaffold protein is regulated by activity-dependent calpain proteolysis and modulates synaptic plasticity.Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory.A reliable way to detect endogenous murine β-amyloidElectrophysiological profiles of induced neurons converted directly from adult human fibroblasts indicate incomplete neuronal conversion.An intracellular threonine of amyloid-β precursor protein mediates synaptic plasticity deficits and memory loss.
P50
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P50
description
onderzoeker
@nl
researcher ORCID ID = 0000-0001-6335-164X
@en
name
Ottavio Arancio
@ast
Ottavio Arancio
@en
Ottavio Arancio
@es
Ottavio Arancio
@nl
type
label
Ottavio Arancio
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Ottavio Arancio
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Ottavio Arancio
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Ottavio Arancio
@nl
prefLabel
Ottavio Arancio
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Ottavio Arancio
@en
Ottavio Arancio
@es
Ottavio Arancio
@nl
P106
P1153
7003543010
P21
P31
P496
0000-0001-6335-164X