about
Enhanced cardiac Akt/protein kinase B signaling contributes to pathological cardiac hypertrophy in part by impairing mitochondrial function via transcriptional repression of mitochondrion-targeted nuclear genes.Early mitochondrial adaptations in skeletal muscle to diet-induced obesity are strain dependent and determine oxidative stress and energy expenditure but not insulin sensitivityNon-metastatic squamous cell carcinoma within a Rathke's cleft cystDiet-induced obesity causes insulin resistance in mouse brown adipose tissue.A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy.Role of PKCδ in Insulin Sensitivity and Skeletal Muscle Metabolism.Cardiac PI3K-Akt impairs insulin-stimulated glucose uptake independent of mTORC1 and GLUT4 translocation.Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis.Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart.Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression.Insulin Regulation of Proteostasis and Clinical Implications.Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and FunctionImpaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts.Glucose transporter 4-deficient hearts develop maladaptive hypertrophy in response to physiological or pathological stresses.Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor.Insulin Downregulates the Transcriptional Coregulator CITED2, an Inhibitor of Proangiogenic Function in Endothelial Cells.Concurrent Intrathyroidal Thyroid Cancer and Thyroid Cancer in Struma Ovarii: A Case Report and Literature Review.
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description
onderzoeker
@nl
researcher ORCID ID = 0000-0002-5685-9805
@en
name
Brian T O'Neill
@ast
Brian T O'Neill
@en
Brian T O'Neill
@es
Brian T O'Neill
@nl
type
label
Brian T O'Neill
@ast
Brian T O'Neill
@en
Brian T O'Neill
@es
Brian T O'Neill
@nl
prefLabel
Brian T O'Neill
@ast
Brian T O'Neill
@en
Brian T O'Neill
@es
Brian T O'Neill
@nl
P106
P1153
57193767257
P31
P496
0000-0002-5685-9805