Defective Toll-like receptor 9-mediated cytokine production in B cells from Bruton's tyrosine kinase-deficient mice
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Bruton's tyrosine kinase and protein kinase C µ are required for TLR7/9-induced IKKα and IRF-1 activation and interferon-β production in conventional dendritic cellsSplice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia modelTLR signaling and effector functions are intact in XLA neutrophils.Toll-like receptor 4-, 7-, and 8-activated myeloid cells from patients with X-linked agammaglobulinemia produce enhanced inflammatory cytokines.Toll-like receptor function in primary B cell defects.Toll-like receptors--sentries in the B-cell response.TLR signaling in B-cell development and activation.Functional role of the nicotinic arm of the acetylcholine regulatory axis in human B-cell lines.Btk regulates localization, in vivo activation, and class switching of anti-DNA B cells.Bruton's tyrosine kinase: from X-linked agammaglobulinemia toward targeted therapy for B-cell malignancies.The Toll-like receptor 9 signalling pathway regulates MR1-mediated bacterial antigen presentation in B cells.Impaired TLR9 responses in B cells from patients with systemic lupus erythematosus.Chronic Lymphocytic Leukemia B-Cell Normal Cellular Counterpart: Clues From a Functional Perspective.First-in-human phase 1 study of the BTK inhibitor GDC-0853 in relapsed or refractory B-cell NHL and CLL.Bruton's tyrosine kinase regulates TLR7/8-induced TNF transcription via nuclear factor-κB recruitment.
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P2860
Defective Toll-like receptor 9-mediated cytokine production in B cells from Bruton's tyrosine kinase-deficient mice
description
article
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в лютому 2008
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name
Defective Toll-like receptor 9 ...... tyrosine kinase-deficient mice
@en
Defective Toll-like receptor 9 ...... tyrosine kinase-deficient mice
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type
label
Defective Toll-like receptor 9 ...... tyrosine kinase-deficient mice
@en
Defective Toll-like receptor 9 ...... tyrosine kinase-deficient mice
@nl
prefLabel
Defective Toll-like receptor 9 ...... tyrosine kinase-deficient mice
@en
Defective Toll-like receptor 9 ...... tyrosine kinase-deficient mice
@nl
P2093
P2860
P1433
P1476
Defective Toll-like receptor 9 ...... tyrosine kinase-deficient mice
@en
P2093
Anna Berglöf
Gabriela Lopez-Herrera
K Emelie M Blomberg
Leonardo Vargas
Maroof Hasan
P2860
P304
P356
10.1111/J.1365-2567.2007.02693.X
P407
P577
2007-08-28T00:00:00Z