Btk regulates localization, in vivo activation, and class switching of anti-DNA B cells.
about
Regulation of nucleocytoplasmic shuttling of Bruton's tyrosine kinase (Btk) through a novel SH3-dependent interaction with ankyrin repeat domain 54 (ANKRD54).SLAP deficiency decreases dsDNA autoantibody productionThe role of tyrosine kinases in systemic lupus erythematosus and their potential as therapeutic targets.Bruton's Tyrosine Kinase Synergizes with Notch2 To Govern Marginal Zone B Cells in Nonobese Diabetic Mice.Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus.MicroRNAs prevent the generation of autoreactive antibodies.The role of Bruton's tyrosine kinase in the development and BCR/TLR-dependent activation of AM14 rheumatoid factor B cells.Inhibitors of B-cell receptor signaling for patients with B-cell malignancies.B-lymphocyte signalling abnormalities and lupus immunopathology.The role of Bruton's tyrosine kinase in autoimmunity and implications for therapy.Intracellular B Lymphocyte Signalling and the Regulation of Humoral Immunity and Autoimmunity.HM71224, a selective Bruton's tyrosine kinase inhibitor, attenuates the development of murine lupus.Overexpression of Fkbp11, a feature of lupus B cells, leads to B cell tolerance breakdown and initiates plasma cell differentiation.Biology and novel treatment options for XLA, the most common monogenetic immunodeficiency in man.Bruton's Tyrosine Kinase Deficiency Inhibits Autoimmune Arthritis in Mice but Fails to Block Immune Complex-Mediated Inflammatory Arthritis.Tyrosine kinase inhibitors impair B-cell immune responses in CML through off-target inhibition of kinases important for cell signaling.Bruton's Tyrosine Kinase, a Component of B Cell Signaling Pathways, Has Multiple Roles in the Pathogenesis of Lupus.Bruton's Tyrosine Kinase Is Not Essential for B Cell Survival beyond Early Developmental Stages.Suppression of glomerulonephritis in lupus-prone NZB × NZW mice by RN486, a selective inhibitor of Bruton's tyrosine kinase.
P2860
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P2860
Btk regulates localization, in vivo activation, and class switching of anti-DNA B cells.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Btk regulates localization, in vivo activation, and class switching of anti-DNA B cells.
@en
type
label
Btk regulates localization, in vivo activation, and class switching of anti-DNA B cells.
@en
prefLabel
Btk regulates localization, in vivo activation, and class switching of anti-DNA B cells.
@en
P2093
P2860
P1433
P1476
Btk regulates localization, in vivo activation, and class switching of anti-DNA B cells.
@en
P2093
Anne B Satterthwaite
Heather L Wright
Kristina E Halcomb
Sandirai Musuka
Toni Gutierrez
P2860
P304
P356
10.1016/J.MOLIMM.2008.08.278
P577
2008-10-11T00:00:00Z