Potent Antimalarial Activity of Two Arenes Linked with Triamine Designed To Have Multiple Interactions with Heme

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Potent Antimalarial Activity of Two Arenes Linked with Triamine Designed To Have Multiple Interactions with Heme

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im Oktober 2018 veröffentlichter wissenschaftlicher Artikel

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scientific article published on 24 September 2018

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wetenschappelijk artikel

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наукова стаття, опублікована в жовтні 2018

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Potent Antimalarial Activity o ...... ultiple Interactions with Heme

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Potent Antimalarial Activity o ...... ultiple Interactions with Heme

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Potent Antimalarial Activity o ...... ultiple Interactions with Heme

@en

Potent Antimalarial Activity o ...... ultiple Interactions with Heme

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Potent Antimalarial Activity o ...... ultiple Interactions with Heme

@en

Potent Antimalarial Activity o ...... ultiple Interactions with Heme

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P1476

Potent Antimalarial Activity o ...... ultiple Interactions with Heme

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Haruto Ishikawa

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Hirohisa Omiya

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Hirokazu Yagi

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Hye-Sook Kim

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Koichi Kato

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Kosuke Yabunaka

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Naoki Umezawa

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Nobuki Kato

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Yoshimi Tomita

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Yosuke Hisamatsu

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P2860

HDP-a novel heme detoxification protein from the malaria parasite

Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum

Heme-binding properties of heme detoxification protein from Plasmodium falciparum

Antimalarial activity and mechanisms of action of two novel 4-aminoquinolines against chloroquine-resistant parasites

Bisquinoline antimalarials: their role in malaria chemotherapy.

Identification of essential histidine residues involved in heme binding and Hemozoin formation in heme detoxification protein from Plasmodium falciparum.

Piperaquine: a resurgent antimalarial drug.

Interplay between malaria, crystalline hemozoin formation, and antimalarial drug action and design.

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency.

Antimalarials increase vesicle pH in Plasmodium falciparum.

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980-985

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scholarly article

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10.1021/ACSMEDCHEMLETT.8B00222

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English

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P478

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Tsunehiko Higuchi

T Satoh

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2018-09-24T00:00:00Z

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30344903

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6187406

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