Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency. - Wikidata - awgldk - TriplyDB

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency.

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency.

http://www.wikidata.org/entity/Q35991524

about

Leaving the lysosome behind: novel developments in autophagy inhibition Autophagy in stem cells.Chloroquine and hydroxychloroquine for cancer therapy You eat what you are: autophagy inhibition as a therapeutic strategy in leukemia Autophagy in cancer Autophagy in malignant transformation and cancer progression Autophagy: a targetable linchpin of cancer cell metabolism Emerging strategies to effectively target autophagy in cancer Targeting mitochondrial metabolism by inhibiting autophagy in BRAF-driven cancers PUMA: a puzzle piece in chloroquine's antimelanoma activity.Autophagy and cancer therapy.Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide A novel glutaminase inhibitor-968 inhibits the migration and proliferation of non-small cell lung cancer cells by targeting EGFR/ERK signaling pathway.Autophagy Inhibition Enhances Sunitinib Efficacy in Clear Cell Ovarian Carcinoma CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers.Methylation silencing of ULK2, an autophagy gene, is essential for astrocyte transformation and tumor growth Combination of AKT inhibition with autophagy blockade effectively reduces ascites-derived ovarian cancer cell viability.Combined autophagy and proteasome inhibition: a phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed/refractory myeloma.Combined MTOR and autophagy inhibition: phase I trial of hydroxychloroquine and temsirolimus in patients with advanced solid tumors and melanoma.Combined autophagy and HDAC inhibition: a phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors (-)-Epigallocatechin-3-gallate induces non-apoptotic cell death in human cancer cells via ROS-mediated lysosomal membrane permeabilization.Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma.Reactive oxygen species and autophagy modulation in non-marine drugs and marine drugs.Identification of a small molecule that induces ATG5-and-cathepsin-l-dependent cell death and modulates polyglutamine toxicity.Discovery of autophagy inhibitors with antiproliferative activity in lung and pancreatic cancer cells.Autophagy, viruses, and intestinal immunity Autophagy mediates tolerance to Staphylococcus aureus alpha-toxin.Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells Effect of pantoprazole to enhance activity of docetaxel against human tumour xenografts by inhibiting autophagy Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction.Autophagy Inhibition Delays Early but Not Late-Stage Metastatic Disease.Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy Effect of hydroxychloroquine and characterization of autophagy in a mouse model of endometriosis Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment.Significantly enhanced tumor cellular and lysosomal hydroxychloroquine delivery by smart liposomes for optimal autophagy inhibition and improved antitumor efficiency with liposomal doxorubicin The anti-malarial chloroquine overcomes primary resistance and restores sensitivity to trastuzumab in HER2-positive breast cancer The autophagy inhibitor verteporfin moderately enhances the antitumor activity of gemcitabine in a pancreatic ductal adenocarcinoma model.Recent insights into the function of autophagy in cancer.The natural compound oblongifolin C inhibits autophagic flux and enhances antitumor efficacy of nutrient deprivation.Autophagy and human diseases.

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P2860

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency.

http://www.wikidata.org/entity/Q35991524

description

2012 nî lūn-bûn

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Autophagy inhibitor Lys05 has ...... genetic autophagy deficiency.

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Autophagy inhibitor Lys05 has ...... genetic autophagy deficiency.

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type

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Autophagy inhibitor Lys05 has ...... genetic autophagy deficiency.

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Autophagy inhibitor Lys05 has ...... genetic autophagy deficiency.

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Autophagy inhibitor Lys05 has ...... genetic autophagy deficiency.

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Autophagy inhibitor Lys05 has ...... genetic autophagy deficiency.

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PNAS.1118193109

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Autophagy inhibitor Lys05 has ...... genetic autophagy deficiency.

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P2093

Antonia R Sepulveda

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Arabinda Samanta

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Jeffrey D Winkler

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John P Lynch

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Lisa E Davis

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Quentin McAfee

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Ravi K Amaravadi

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Samuel M Levi

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Shengfu Piao

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Takeshi Uehara

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P2860

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

Akt and autophagy cooperate to promote survival of drug-resistant glioma

LC3 conjugation system in mammalian autophagy

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

Pancreatic cancers require autophagy for tumor growth

Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma

Unconventional secretion of Pichia pastoris Acb1 is dependent on GRASP protein, peroxisomal functions, and autophagosome formation.

Principles and current strategies for targeting autophagy for cancer treatment.

Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance.

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