Trans -splicing ribozymes for targeted gene delivery 1 1Edited by J. Karn
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Suppression of the Arboviruses Dengue and Chikungunya Using a Dual-Acting Group-I Intron Coupled with Conditional Expression of the Bax C-Terminal DomainIn vitro selection, characterization, and application of deoxyribozymes that cleave RNAEmerging clinical applications of RNAHeterologous HIV-nef mRNA trans-splicing: a new principle how mammalian cells generate hybrid mRNA and protein molecules.Optimization of trans-splicing ribozyme efficiency and specificity by in vivo genetic selection.Targeting of highly conserved Dengue virus sequences with anti-Dengue virus trans-splicing group I introns.Engineering a family of synthetic splicing ribozymes.Effective suppression of dengue virus using a novel group-I intron that induces apoptotic cell death upon infection through conditional expression of the Bax C-terminal domainEvaluating group I intron catalytic efficiency in mammalian cells.Evaluating target silencing by short hairpin RNA mediated by the group I intron in cultured mammalian cellsAn in vivo selection method to optimize trans-splicing ribozymesIntracellular ribozyme-catalyzed trans-cleavage of RNA monitored by fluorescence resonance energy transfer.Efficient and specific repair of sickle beta-globin RNA by trans-splicing ribozymes.Design and Experimental Evolution of trans-Splicing Group I Intron Ribozymes.Variables and strategies in development of therapeutic post-transcriptional gene silencing agentsRibozyme-mediated revision of RNA and DNASpliceozymes: ribozymes that remove introns from pre-mRNAs in trans.Engineered ribozymes as molecular tools for site-specific alteration of RNA sequence.Computational prediction of efficient splice sites for trans-splicing ribozymes.Design of highly specific cytotoxins by using trans-splicing ribozymes.Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts.Low selection pressure aids the evolution of cooperative ribozyme mutations in cellsGroup I introns and inteins: disparate origins but convergent parasitic strategies.Molecular recognition properties of IGS-mediated reactions catalyzed by a Pneumocystis carinii group I intron.Specific and Efficient Regression of Cancers Harboring KRAS Mutation by Targeted RNA Replacement.Trans-splicing group I intron targeting hepatitis C virus IRES mediates cell death upon viral infection in Huh7.5 cells.RNA double cleavage by a hairpin-derived twin ribozyme.Intracellular efficacy of tumor-targeting group I intron-based trans-splicing ribozyme.Selections for constituting new RNA-protein interactions in catalytic RNP.Functional repair of a mutant chloride channel using a trans-splicing ribozymeIn vivo excision of a single targeted nucleotide from an mRNA by a trans excision-splicing ribozymeTrans-splicing with the group I intron ribozyme from Azoarcus.Increased efficiency of evolved group I intron spliceozymes by decreased side product formation.Selective and efficient retardation of cancers expressing cytoskeleton-associated protein 2 by targeted RNA replacement.Heterodimerization of Group I Ribozymes Enabling Exon Recombination through Pairs of Cooperative trans-Splicing Reactions.Trans-splicing of a mutated glycosylasparaginase mRNA sequence by a group I ribozyme deficient in hydrolysis.
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Trans -splicing ribozymes for targeted gene delivery 1 1Edited by J. Karn
description
article
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im Februar 1999 veröffentlichter wissenschaftlicher Artikel
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wetenschappelijk artikel
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наукова стаття, опублікована в лютому 1999
@uk
name
Trans -splicing ribozymes for targeted gene delivery 1 1Edited by J. Karn
@en
Trans -splicing ribozymes for targeted gene delivery 1 1Edited by J. Karn
@nl
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Trans -splicing ribozymes for targeted gene delivery 1 1Edited by J. Karn
@en
Trans -splicing ribozymes for targeted gene delivery 1 1Edited by J. Karn
@nl
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Trans -splicing ribozymes for targeted gene delivery 1 1Edited by J. Karn
@en
Trans -splicing ribozymes for targeted gene delivery 1 1Edited by J. Karn
@nl
P356
P1476
Trans -splicing ribozymes for targeted gene delivery 1 1Edited by J. Karn
@en
P2093
Howard M Goodman
Uwe Köhler
P304
P356
10.1006/JMBI.1998.2447
P407
P577
1999-02-01T00:00:00Z