Overexpression of the hereditary hemochromatosis protein, HFE, in HeLa cells induces an iron-deficient phenotype
about
Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFERegulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis.Pumping iron: the strange partnership of the hemochromatosis protein, a class I MHC homolog, with the transferrin receptor.The hemochromatosis protein HFE inhibits iron export from macrophages.Physiology of iron transport and the hemochromatosis gene.Molecular mechanisms and regulation of iron transport.Mechanisms of HFE-induced regulation of iron homeostasis: Insights from the W81A HFE mutation.Impact of hemochromatosis gene (HFE) mutations on epithelial ovarian cancer risk and prognosisIron Imports. VI. HFE and regulation of intestinal iron absorption.The regulation of cellular iron metabolism.Expression of the hemochromatosis gene modulates the cytotoxicity of doxorubicin in breast cancer cells.Expression of the hereditary hemochromatosis protein HFE increases ferritin levels by inhibiting iron export in HT29 cells.Increased IRP1 and IRP2 RNA binding activity accompanies a reduction of the labile iron pool in HFE-expressing cells.Interactions of the ectodomain of HFE with the transferrin receptor are critical for iron homeostasis in cells.HFE and transferrin directly compete for transferrin receptor in solution and at the cell surface.HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions.Overexpression of wild type and mutated human ferritin H-chain in HeLa cells: in vivo role of ferritin ferroxidase activity.
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P2860
Overexpression of the hereditary hemochromatosis protein, HFE, in HeLa cells induces an iron-deficient phenotype
description
im Oktober 1999 veröffentlichter wissenschaftlicher Artikel
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scientific article published on 01 October 1999
@en
wetenschappelijk artikel
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наукова стаття, опублікована в жовтні 1999
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name
Overexpression of the heredita ...... es an iron-deficient phenotype
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Overexpression of the heredita ...... es an iron-deficient phenotype
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type
label
Overexpression of the heredita ...... es an iron-deficient phenotype
@en
Overexpression of the heredita ...... es an iron-deficient phenotype
@nl
prefLabel
Overexpression of the heredita ...... es an iron-deficient phenotype
@en
Overexpression of the heredita ...... es an iron-deficient phenotype
@nl
P2093
P2860
P50
P921
P1433
P1476
Overexpression of the heredita ...... s and iron-deficient phenotype
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P2093
P2860
P304
P356
10.1016/S0014-5793(99)01330-7
P407
P577
1999-10-01T00:00:00Z