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Molecular basis for beta-glucosidase inhibition by ring-modified calystegine analogues6-Amino-6-deoxy-5,6-di-N-(N'-octyliminomethylidene)nojirimycin: synthesis, biological evaluation, and crystal structure in complex with acid beta-glucosidaseGlycosidase inhibition by ring-modified castanospermine analogues: tackling enzyme selectivity by inhibitor tailoringCyclodextrin-mediated crystallization of acid β-glucosidase in complex with amphiphilic bicyclic nojirimycin analoguesMolecular basis of 1-deoxygalactonojirimycin arylthiourea binding to human α-galactosidase a: pharmacological chaperoning efficacy on Fabry disease mutantsInfluence of the macroring size on the self-association thermodynamics of cyclodextrins with a double-linked naphthalene at the secondary face.Castanospermine-trehazolin hybrids: a new family of glycomimetics with tuneable glycosidase inhibitory properties.Urea-, thiourea-, and guanidine-linked glycooligomers as phosphate binders in water.Synthesis and biological evaluation of guanidine-type iminosugars.Structure and serological analysis of the Hafnia alvei 481-L O-specific polysaccharide containing phosphate in the backbone chain.Sugar-modified foldamers as conformationally defined and biologically distinct glycopeptide mimicsNeuronopathic Gaucher's disease: induced pluripotent stem cells for disease modelling and testing chaperone activity of small compounds.Effects of inulin and di-D-fructose dianhydride-enriched caramels on intestinal microbiota composition and performance of broiler chickens.Cyclodextrin- and calixarene-based polycationic amphiphiles as gene delivery systems: a structure-activity relationship study.Pharmacological Chaperones and Coenzyme Q10 Treatment Improves Mutant β-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease.pH-Responsive Pharmacological Chaperones for Rescuing Mutant Glycosidases.(Pseudo)amide-linked oligosaccharide mimetics: molecular recognition and supramolecular properties.Cyclodextrin-based gene delivery systems.Pharmacological chaperone therapy for Gaucher disease: a patent review.Multivalency in heterogeneous glycoenvironments: hetero-glycoclusters, -glycopolymers and -glycoassemblies.Cyclodextrin-based multivalent glycodisplays: covalent and supramolecular conjugates to assess carbohydrate-protein interactions.Influence of the configurational pattern of sp(2)-iminosugar pseudo N-, S-, O- and C-glycosides on their glycoside inhibitory and antitumor properties.Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, GM1-gangliosidosis and Fabry diseases.Host-Guest-Mediated DNA Templation of Polycationic Supramolecules for Hierarchical Nanocondensation and the Delivery of Gene Material.Inhibition of type 1 fimbriae-mediated Escherichia coli adhesion and biofilm formation by trimeric cluster thiomannosides conjugated to diamond nanoparticles.Targeted gene delivery by new folate-polycationic amphiphilic cyclodextrin-DNA nanocomplexes in vitro and in vivo.Bicyclic derivatives of L-idonojirimycin as pharmacological chaperones for neuronopathic forms of Gaucher disease.Polycationic amphiphilic cyclodextrin-based nanoparticles for therapeutic gene delivery.Potent Glycosidase Inhibition with Heterovalent Fullerenes: Unveiling the Binding Modes Triggering Multivalent Inhibition.Synthesis of N-, S-, and C-glycoside castanospermine analogues with selective neutral alpha-glucosidase inhibitory activity as antitumour agents.Structural basis of pharmacological chaperoning for human β-galactosidase.Tailoring beta-cyclodextrin for DNA complexation and delivery by homogeneous functionalization at the secondary face.A bicyclic 1-deoxygalactonojirimycin derivative as a novel pharmacological chaperone for GM1 gangliosidosis.Trehalose- and glucose-derived glycoamphiphiles: small-molecule and nanoparticle Toll-like receptor 4 (TLR4) modulators.Fluorescent-tagged sp2-iminosugars with potent β-glucosidase inhibitory activity.Di-D-fructose dianhydride-enriched caramels: effect on colon microbiota, inflammation, and tissue damage in trinitrobenzenesulfonic acid-induced colitic rats.Di-D-fructose dianhydride-enriched products by acid ion-exchange resin-promoted caramelization of D-fructose: chemical analyses.Carbohydrate-based receptors with multiple thiourea binding sites. Multipoint hydrogen bond recognition of dicarboxylates and monosaccharides.Dependence of concanavalin A binding on anomeric configuration, linkage type, and ligand multiplicity for thiourea-bridged mannopyranosyl-beta-cyclodextrin conjugates.One-step synthesis of non-anomeric sugar isothiocyanates from sugar azides.
P50
Q27652390-F6B0185A-9133-435A-9C8B-62EF650B0DF6Q27655457-2CC477DA-9014-4165-8051-01D8F76443BAQ27655995-F89AE10A-852D-45AB-AA35-3A75B88FF318Q27667205-0485AC56-A221-4E2F-A5EA-6DFA02592BCEQ27690129-30F382C7-FD54-459E-AFE3-1A9AA4AF22C2Q30617271-267C724F-F094-4F78-BA21-6C57F3C955F3Q30704789-EF92D622-2FFC-43AA-A16B-AB8812680335Q31047485-DF4572C3-7E7C-41CC-8A50-E3E8CEBB1FFBQ31143573-67472DDA-6210-4382-B624-238ACA1C2E20Q33262533-06AABBA0-A78C-4F1D-9E88-D2487D24DC84Q34205779-BE95DAF4-1DEA-45A7-AD56-30A8627EB8FEQ34464236-E7FA4407-AFFF-4266-8568-C5D36F5D3856Q34982199-5D4004B6-D6FD-4E55-807E-8DB15DF09AA5Q35488349-F3397824-C2BB-4A4B-9CC7-68F801A2AB6CQ35686212-52F98E86-B7A8-4EEA-B0E3-68F66B9BF21EQ35781202-256CBF9A-B89C-41B0-95A7-BC3A6DD8825BQ37756536-2131B800-6ED4-4FA6-8BAD-D01645F496E4Q37806096-D4630C82-2F78-470F-95E7-5F900ADBFFB3Q37860332-8275573F-D892-4D9D-8F44-E723A5EEC380Q38036582-3DBB8F8E-D000-4894-85F1-E8D62EDEEFAEQ38076027-05176D38-03EC-4B88-9891-FD37CD6A3479Q38796094-83BD498F-6CD4-44C2-A81E-268B53A40FF8Q38797648-9EBF0A02-5A57-47C0-AF8E-EE3FA59AAAE2Q38851910-8052B2F4-CFDA-41A1-8D41-358B2813526DQ38923171-04203B83-EDE2-4F72-835E-7D7B49A1EBF9Q39133271-E37DEA1D-CC91-49AB-9719-ECE719C92E04Q39162679-CFE56EF7-BE3B-441C-9726-B8575A831E67Q39436385-F2AC2921-C1E7-4CB6-BF38-48B3930A562BQ39635191-709E7B5E-6B43-4E28-B6CD-E79F514FC397Q39692460-E13159BC-974E-4F55-A5AA-104D7A83521FQ39885525-D0D42B5D-1F67-42F2-A515-8DD95C61FA90Q39927077-6F6B2C73-BDB0-4D33-8A6B-4C7C0B70D47EQ41574484-D6940A66-2F88-44D1-B99A-BF859B1D8B0AQ41721678-7D892848-68B6-4787-B1A6-8A9DB77C9EE1Q42871238-9F6D186A-F8AA-4957-BA32-896753B964D1Q43084156-5528C9DD-6145-4409-96DD-2C60CB9E4FE7Q43205686-9ED0C3A7-0F6D-4CDF-AA29-4943D2B82EF9Q43582540-1924EC15-D813-4820-B3B4-6D149E04C020Q43956465-5C87ED3F-D60D-4BEB-A7E9-1E0BBE6AD3A4Q44217642-863EDABF-A07F-45A2-8C7D-389F0BE2111D
P50
description
researcher, ORCID id # 0000-0002-6827-0387
@en
wetenschapper
@nl
name
José Manuel García Fernández
@ast
José Manuel García Fernández
@en
José Manuel García Fernández
@es
José Manuel García Fernández
@nl
type
label
José Manuel García Fernández
@ast
José Manuel García Fernández
@en
José Manuel García Fernández
@es
José Manuel García Fernández
@nl
altLabel
Jose Manuel Garcia Fernández
@en
prefLabel
José Manuel García Fernández
@ast
José Manuel García Fernández
@en
José Manuel García Fernández
@es
José Manuel García Fernández
@nl
P1053
D-8105-2011
P106
P1153
7103378483
P21
P2798
P31
P496
0000-0002-6827-0387