Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response - Wikidata - awgldk - TriplyDB

Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response

Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response

http://www.wikidata.org/entity/Q57998597

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Triazolo[4,5]pyrimidines as Validated General Control Nonderepressible 2 (GCN2) Protein Kinase Inhibitors Reduce Growth of Leukemia Cells

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Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response

http://www.wikidata.org/entity/Q57998597

description

article published in the Proce ...... f the United States of America

@en

article publié dans les Procee ...... f the United States of America

@fr

im August 2018 veröffentlichter wissenschaftlicher Artikel

@de

wetenschappelijk artikel

@nl

наукова стаття, опублікована в серпні 2018

@uk

name

Inhibition of GCN2 sensitizes ...... upting the amino acid response

@en

Inhibition of GCN2 sensitizes ...... upting the amino acid response

@nl

type

label

Inhibition of GCN2 sensitizes ...... upting the amino acid response

@en

Inhibition of GCN2 sensitizes ...... upting the amino acid response

@nl

prefLabel

Inhibition of GCN2 sensitizes ...... upting the amino acid response

@en

Inhibition of GCN2 sensitizes ...... upting the amino acid response

@nl

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PNAS.1805523115

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Inhibition of GCN2 sensitizes ...... upting the amino acid response

@en

P2093

Akito Hata

http://www.w3.org/2001/XMLSchema#string

Akito Nakamura

http://www.w3.org/2001/XMLSchema#string

Ayumi Ando

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Chisato Takahara

http://www.w3.org/2001/XMLSchema#string

Daisuke Tomita

http://www.w3.org/2001/XMLSchema#string

Jun Fujimoto

http://www.w3.org/2001/XMLSchema#string

Kosei Toyoshima

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Ryuichi Nishigaki

http://www.w3.org/2001/XMLSchema#string

Shunsuke Ebara

http://www.w3.org/2001/XMLSchema#string

Tadahiro Nambu

http://www.w3.org/2001/XMLSchema#string

P2860

ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene

The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids

How to manage asparaginase hypersensitivity in acute lymphoblastic leukemia

Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression.

Evidence that the L-asparaginase of guinea pig serum is responsible for its antilymphoma effects. I. Properties of the L-asparaginase of guinea pig serum in relation to those of the antilymphoma substance

Multiple adaptive mechanisms affect asparagine synthetase substrate availability in asparaginase-resistant MOLT-4 human leukaemia cells

Regulated translation initiation controls stress-induced gene expression in mammalian cells

Amino acid control of asparagine synthetase: relation to asparaginase resistance in human leukemia cells

Activation of GCN2 in UV-irradiated cells inhibits translation

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

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E7776-E7785

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scholarly article

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10.1073/PNAS.1805523115

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33

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115

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Yoshinori Satomi

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2018-08-14T00:00:00Z

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30061420

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6099884

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