about
Using a biologically annotated library to analyze the anticancer mechanism of serine palmitoyl transferase (SPT) inhibitors.Synthesis and properties of oligodeoxynucleotides incorporating a conformationally rigid uridine unit having a cyclic structure at the 5'-terminal site.CCR5 antagonists as anti-HIV-1 agents. 1. Synthesis and biological evaluation of 5-oxopyrrolidine-3-carboxamide derivatives.Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones.2-Aminomethylthieno[3,2-d]pyrimidin-4(3H)-ones bearing 3-methylpyrazole hinge binding moiety: Highly potent, selective, and time-dependent inhibitors of Cdc7 kinase.Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents.Synthesis and Properties of Conformationally Rigid Cyclouridylic Acids Having Covalent Bonding Linkers Between the Uracil 5-Position and the 5′-Phosphate GroupInhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid responseMolecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitorSynthesis and properties of oligonucleotides having a phosphorus chiral center by incorporation of conformationally rigid 5'-cyclouridylic acid derivativesDiscovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB)Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockersDiscovery of Novel Allosteric Inhibitors of Deoxyhypusine SynthaseIdentification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding ModeDiscovery of a Novel, Highly Potent, and Selective Thieno[3,2-d]pyrimidinone-Based Cdc7 Inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Antitumor Agent
P50
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P50
description
onderzoeker
@nl
researcher, ORCID id # 0000-0001-5313-3753
@en
name
Osamu Kurasawa
@ast
Osamu Kurasawa
@en
Osamu Kurasawa
@es
Osamu Kurasawa
@nl
type
label
Osamu Kurasawa
@ast
Osamu Kurasawa
@en
Osamu Kurasawa
@es
Osamu Kurasawa
@nl
prefLabel
Osamu Kurasawa
@ast
Osamu Kurasawa
@en
Osamu Kurasawa
@es
Osamu Kurasawa
@nl
P106
P1153
6507207766
P31
P496
0000-0001-5313-3753