about
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's diseaseToward more predictive genetic mouse models of Alzheimer's diseaseGenetics ignite focus on microglial inflammation in Alzheimer's diseaseNext generation sequencing techniques in neurological diseases: redefining clinical and molecular associations.Coding variants in TREM2 increase risk for Alzheimer's diseaseAlzheimer's disease risk genes and mechanisms of disease pathogenesisFrontobasal gray matter loss is associated with the TREM2 p.R47H variantMutation analysis of patients with neurodegenerative disorders using NeuroX arrayTREM2 R47H variant and risk of essential tremor: a cross-sectional international multicenter study.TREM2 is associated with increased risk for Alzheimer's disease in African Americans.microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular DegenerationR47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementiaThe role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease.TREM2 regulates microglial cell activation in response to demyelination in vivo.Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's disease.Resequencing analysis of five Mendelian genes and the top genes from genome-wide association studies in Parkinson's Disease.Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation.Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status.TREM2 p.R47H substitution is not associated with dementia with Lewy bodies.Missense variant in TREML2 protects against Alzheimer's disease.Preparation, crystallization, and preliminary crystallographic analysis of wild-type and mutant human TREM-2 ectodomains linked to neurodegenerative and inflammatory diseasesThe Role of TREM2 in Alzheimer's Disease and Other Neurological Disorders.TREM2 in Neurodegenerative Diseases.Deficits in the miRNA-34a-regulated endogenous TREM2 phagocytosis sensor-receptor in Alzheimer's disease (AD); an updateAssociation of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population.Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels.Assessment of the Genetic Architecture of Alzheimer's Disease Risk in Rate of Memory Decline.Pleiotropic Effects of Variants in Dementia Genes in Parkinson Disease.The polymorphism rs6918289 located in the downstream region of the TREM2 gene is associated with TNF-α levels and IMT-F.Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure.Microglial TREM2/DAP12 Signaling: A Double-Edged Sword in Neural Diseases
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description
im Oktober 2013 veröffentlichter wissenschaftlicher Artikel
@de
наукова стаття, опублікована в жовтні 2013
@uk
name
TREM2 and neurodegenerative disease
@en
type
label
TREM2 and neurodegenerative disease
@en
prefLabel
TREM2 and neurodegenerative disease
@en
P2860
P1476
TREM2 and neurodegenerative disease
@en
P2093
Carlos Cruchaga
P2860
P304
P356
10.1056/NEJMC1306509#SA4
P407
P577
2013-10-17T00:00:00Z