Macrolide-ketolide inhibition of MLS-resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA
about
Impact of ribosomal modification on the binding of the antibiotic telithromycin using a combined grand canonical monte carlo/molecular dynamics simulation approachTelithromycin: a new ketolide antimicrobial for treatment of respiratory tract infections.Ketolide resistance in Streptococcus pyogenes correlates with the degree of rRNA dimethylation by Erm.ABT-773: a new ketolide antibiotic.23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A-->G.Overcoming antimicrobial resistance by targeting resistance mechanisms.Ketolides: an emerging treatment for macrolide-resistant respiratory infections, focusing on S. pneumoniae.Telithromycin: an oral ketolide for respiratory infections.Pneumococcal resistance to macrolides, lincosamides, ketolides, and streptogramin B agents: molecular mechanisms and resistance phenotypes.Telithromycin: the first of the ketolides.Novel antibacterial agents for the treatment of serious Gram-positive infections.Structural insight into functional aspects of ribosomal RNA targeting.Drug efflux pump deficiency and drug target resistance masking in growing bacteriaMycoplasma pneumoniae 23S rRNA A2063G mutation does not influence chest radiography features in children with pneumonia.Toward the rational design of macrolide antibiotics to combat resistance.Mycoplasma bovis isolates from dairy calves in Japan have less susceptibility than a reference strain to all approved macrolides associated with a point mutation (G748A) combined with multiple species-specific nucleotide alterations in 23S rRNA.Synthesis and structure-activity relationships of novel lincomycin derivatives. Part 1. Newly generated antibacterial activities against Gram-positive bacteria with erm gene by C-7 modification.Macrolide therapy in chronic inflammatory diseases.Investigating the entire course of telithromycin binding to Escherichia coli ribosomes.Parametrization of macrolide antibiotics using the force field toolkit.Effects of itraconazole or grapefruit juice on the pharmacokinetics of telithromycin.Refinement of a low-resolution crystal structure to better understand erythromycin interactions on large ribosomal subunit.Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins.
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P2860
Macrolide-ketolide inhibition of MLS-resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA
description
im April 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published on 01 April 2000
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована у квітні 2000
@uk
name
Macrolide-ketolide inhibition ...... ion with domain II of 23S rRNA
@en
Macrolide-ketolide inhibition ...... ion with domain II of 23S rRNA
@nl
type
label
Macrolide-ketolide inhibition ...... ion with domain II of 23S rRNA
@en
Macrolide-ketolide inhibition ...... ion with domain II of 23S rRNA
@nl
prefLabel
Macrolide-ketolide inhibition ...... ion with domain II of 23S rRNA
@en
Macrolide-ketolide inhibition ...... ion with domain II of 23S rRNA
@nl
P2860
P1476
Macrolide-ketolide inhibition ...... ion with domain II of 23S rRNA
@en
P2093
P2860
P304
P356
10.1046/J.1365-2958.2000.01841.X
P407
P577
2000-04-01T00:00:00Z