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Protein-Directed Dynamic Combinatorial Chemistry: A Guide to Protein Ligand and Inhibitor DiscoveryInvestigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygenγ-Butyrobetaine hydroxylase catalyses a Stevens type rearrangementStructural and mechanistic studies on γ-butyrobetaine hydroxylasePotent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine BrainHuman oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylationDynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.Studies on the Glutathione-Dependent Formaldehyde-Activating Enzyme from Paracoccus denitrificansNon-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases.Virtual screening and biophysical studies lead to HSP90 inhibitors.Fluoromethylated derivatives of carnitine biosynthesis intermediates--synthesis and applications.Targeting isocitrate lyase for the treatment of latent tuberculosis.Protein-ligand binding affinity determination by the waterLOGSY method: An optimised approach considering ligand rebinding.NMR studies of the non-haem Fe(II) and 2-oxoglutarate-dependent oxygenases.Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor.Harnessing ester bond chemistry for protein ligation.Total Synthesis and Conformational Study of Callyaerin A: Anti-Tubercular Cyclic Peptide Bearing a Rare Rigidifying (Z)-2,3- Diaminoacrylamide Moiety.Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials.Synthesis of the Azepinobisindole Alkaloid Iheyamine A Enabled by a Cross-Mannich Reaction.2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2.Studies on deacetoxycephalosporin C synthase support a consensus mechanism for 2-oxoglutarate dependent oxygenases.Non-competitive cyclic peptides for targeting enzyme-substrate complexes.MCR-1: a promising target for structure-based design of inhibitors to tackle polymyxin resistanceA Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2-chromen-4-ol ScaffoldStudies on the Substrate Selectivity of the Hypoxia-Inducible Factor Prolyl Hydroxylase 2 Catalytic DomainComparison of the substrate selectivity and biochemical properties of human and bacterial γ-butyrobetaine hydroxylaseDiphenylacetylene-Linked Peptide Strands Induce Bidirectional β-Sheet FormationThe Ugi four-component reaction enables expedient synthesis and comparison of photoaffinity probesTotal synthesis of the proposed structure of talarolide ACyclization of Linear Tetrapeptides Containing N -Methylated Amino Acids by using 1-Propanephosphonic Acid AnhydrideDevelopment of NMR and thermal shift assays for the evaluation of isocitrate lyase inhibitorsAn improved method for the heterologous production of soluble human ribosomal proteins in Escherichia coli.Effect of consecutive rare codons on the recombinant production of human proteins in Escherichia coliNovel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane FragmentsAcetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 InhibitorsProtein-Small Molecule Interactions by WaterLOGSYIdentification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90)An approach to recombinantly produce mature grape polyphenol oxidase
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description
researcher, ORCID id # 0000-0003-0633-6771
@en
wetenschapper
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name
Ivanhoe K. H. Leung
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Ivanhoe K. H. Leung
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Ivanhoe K. H. Leung
@es
Ivanhoe K. H. Leung
@nl
type
label
Ivanhoe K. H. Leung
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Ivanhoe K. H. Leung
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Ivanhoe K. H. Leung
@es
Ivanhoe K. H. Leung
@nl
prefLabel
Ivanhoe K. H. Leung
@ast
Ivanhoe K. H. Leung
@en
Ivanhoe K. H. Leung
@es
Ivanhoe K. H. Leung
@nl
P106
P1153
6701823432
P31
P496
0000-0003-0633-6771