about
Frizzled7: A Promising Achilles' Heel for Targeting the Wnt Receptor Complex to Treat CancerThe core planar cell polarity gene prickle interacts with flamingo to promote sensory axon advance in the Drosophila embryoPHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis.Intestinal epithelial-specific PTEN inactivation results in tumor formation.Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo.Winding back Wnt signalling: potential therapeutic targets for treating gastric cancers.Wnt is necessary for mesenchymal to epithelial transition in colorectal cancer cells.Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cellsPartial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.The Central Role of Wnt Signaling and Organoid Technology in Personalizing Anticancer Therapy.Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical Model.
P50
Q26747651-B0BD3778-5B16-474A-87F4-2EFFE898024AQ29541172-EB8E73BF-D60C-4EB7-9CB9-EAD1FA71D1BAQ34184024-73812F86-BEA3-409B-BD3C-498693C30F62Q35562094-30BFFBD7-072F-4A8B-991E-60B214F42CE6Q38733090-5E365D80-C8C1-4C85-A447-5ECCAAF1875FQ38751688-6798BEE6-893F-499D-A751-254304C6D165Q40191438-51EB3FF0-C7C4-4AE4-B7FD-13C36095BC6BQ40843426-28F4A7BC-307A-4B16-9A12-758FD1F5289EQ41721009-BFF47859-6008-478D-AC7D-1C0226CD7744Q49493239-C3DB042D-8232-472E-BE0B-355B67CBF397Q50543170-89D765D8-5063-4CEE-AF01-4564FEC07DC1
P50
description
onderzoeker
@nl
researcher, ORCID id # 0000-0002-3915-8281
@en
name
Dustin J Flanagan
@ast
Dustin J Flanagan
@en
Dustin J Flanagan
@nl
type
label
Dustin J Flanagan
@ast
Dustin J Flanagan
@en
Dustin J Flanagan
@nl
prefLabel
Dustin J Flanagan
@ast
Dustin J Flanagan
@en
Dustin J Flanagan
@nl
P106
P31
P496
0000-0002-3915-8281