about
Altered longevity-assurance activity of p53:p44 in the mouse causes memory loss, neurodegeneration and premature deathNMDA and dopamine converge on the NMDA-receptor to induce ERK activation and synaptic depression in mature hippocampusMetabolic regulation of neuronal plasticity by the energy sensor AMPKMAPK recruitment by beta-amyloid in organotypic hippocampal slice cultures depends on physical state and exposure timeReversal of fragile X phenotypes by manipulation of AβPP/Aβ levels in Fmr1KO micePin1 and PKMzeta sequentially control dendritic protein synthesis.Potent anti-seizure effects of D-leucine.ERK/MAPK regulates hippocampal histone phosphorylation following contextual fear conditioningReduced juvenile long-term depression in tuberous sclerosis complex is mitigated in adults by compensatory recruitment of mGluR5 and Erk signaling.The amyloid precursor protein (APP) intracellular domain regulates translation of p44, a short isoform of p53, through an IRES-dependent mechanism.Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse.The role of Homer1c in metabotropic glutamate receptor-dependent long-term potentiation.Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k.Rescue of synaptic plasticity and spatial learning deficits in the hippocampus of Homer1 knockout mice by recombinant Adeno-associated viral gene delivery of Homer1c.Regulation of histone acetylation during memory formation in the hippocampus.Environmental enrichment improves hippocampal function in aged rats by enhancing learning and memory, LTP, and mGluR5-Homer1c activity.Regulation of nuclear factor kappaB in the hippocampus by group I metabotropic glutamate receptors.Aß Facilitates LTD at Schaffer Collateral Synapses Preferentially in the Left Hippocampus.Physiological activation of mGlu5 receptors supports the ion channel function of NMDA receptors in hippocampal LTD induction in vivo.Induction of Metabotropic Glutamate Receptor-Mediated Long-Term Depression in the Hippocampal Schaffer Collateral Pathway of Aging Rats
P50
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P50
description
researcher, ORCID id # 0000-0003-0081-6010
@en
wetenschapper
@nl
name
Kenneth J O'Riordan
@ast
Kenneth J O'Riordan
@en
Kenneth J O'Riordan
@es
Kenneth J O'Riordan
@nl
type
label
Kenneth J O'Riordan
@ast
Kenneth J O'Riordan
@en
Kenneth J O'Riordan
@es
Kenneth J O'Riordan
@nl
prefLabel
Kenneth J O'Riordan
@ast
Kenneth J O'Riordan
@en
Kenneth J O'Riordan
@es
Kenneth J O'Riordan
@nl
P106
P1153
6603273780
P21
P31
P496
0000-0003-0081-6010