about
Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist.Structural requirements of nociceptin antagonist Ac-RYYRIK-NH2 for receptor binding.Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR)Pharmacological characterization of tachykinin tetrabranched derivatives.Historical review: Negative efficacy and the constitutive activity of G-protein-coupled receptors.Ligands raise the constraint that limits constitutive activation in G protein-coupled opioid receptors.Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activationWhat is biased efficacy? Defining the relationship between intrinsic efficacy and free energy coupling.Morphine-like opiates selectively antagonize receptor-arrestin interactions.Differential roles of two consecutive phenylalanine residues in thrombin receptor-tethered ligand peptides (SFFLRNP) in thrombin receptor activation.Cholera toxin ADP-ribosylates the receptor-coupled form of pertussis toxin-sensitive G-proteins.Cell contact-dependent functional selectivity of β2-adrenergic receptor ligands in stimulating cAMP accumulation and extracellular signal-regulated kinase phosphorylationMutations inducing divergent shifts of constitutive activity reveal different modes of binding among catecholamine analogues to the beta(2)-adrenergic receptorFine spatial assembly for construction of the phenol-binding pocket to capture bisphenol A in the human nuclear receptor estrogen-related receptor γ.Spare interactions of highly potent [Arg(14),Lys(15)]nociceptin for cooperative induction of ORL1 receptor activation.Discriminatory synergistic effect of Trp-substitutions in superagonist [(Arg/Lys)(14), (Arg/Lys)(15)]nociceptin on ORL1 receptor binding and activation.Sodium regulation of opioid agonist binding is potentiated by pertussis toxin.Opioid antinociception and positive reinforcement are mediated by different types of opioid receptors.A very high affinity opioid binding site in rat brain: demonstration by computer modeling.Guanine nucleotide-mediated inhibition of opioid agonist binding. Modulatory effects of ions and of receptor occupancy.Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation."Induced-fit" mechanism for catecholamine binding to the beta2-adrenergic receptor.Divergent agonist selectivity in activating β1- and β2-adrenoceptors for G-protein and arrestin coupling.The molecular size of multiple opiate receptors.Where have all the active receptor states gone?Allosteric coupling and conformational fluctuations in proteins.Is the benzodiazepine receptor coupled to a chloride anion channel?Thrombin is a regulator of astrocytic endothelin-1.Importance of the stereo-orientation of aromatic groups in enkephalins to opiate receptor recognition.Dimeric tetrapeptide enkephalins display extraordinary selectivity for the delta opiate receptor.Functional complementation of high-efficiency resonance energy transfer: a new tool for the study of protein binding interactions in living cells.Agonist efficacy and allosteric models of receptor action.Synthesis and structure-activity relationship studies in serotonin 5-HT4 receptor ligands based on a benzo[de][2,6]naphthridine scaffold.Enkephalin dimers: regulation of cyclic AMP levels in NG108-15 cells.Uncoupling of receptors is essential for opiate-induced desensitization (tolerance) in neuroblastoma x glioma hybrid cells NG 108-15.Pertussis toxin decreases opiate receptor binding and adenylate inhibition in a neuroblastoma x glioma hybrid cell line.Differential effects of GTP and cations on binding of labeled dimeric and monomeric enkephalins to neuroblastoma-glioma cell delta opiate receptors.Thrombin is the major serum factor stimulating phosphoinositide turnover, but not DNA synthesis in human neuroblastoma SH-EP cellsDirect modulation of voltage-dependent calcium channels by muscarinic activation of a pertussis toxin-sensitive G-protein in hippocampal neuronsEffects of sodium and GTP on the binding kinetics of [3H]diprenorphine in NG 108-15 cell membranes
P50
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P50
description
researcher, ORCID id # 0000-0002-8729-3357
@en
name
Tommaso Costa
@ast
Tommaso Costa
@en
Tommaso Costa
@es
Tommaso Costa
@nl
type
label
Tommaso Costa
@ast
Tommaso Costa
@en
Tommaso Costa
@es
Tommaso Costa
@nl
prefLabel
Tommaso Costa
@ast
Tommaso Costa
@en
Tommaso Costa
@es
Tommaso Costa
@nl
P108
P106
P21
P31
P496
0000-0002-8729-3357