Small-Molecule Inhibitors and Probes for Ubiquitin- and Ubiquitin-Like-Specific Proteases - Wikidata - awgldk - TriplyDB

Small-Molecule Inhibitors and Probes for Ubiquitin- and Ubiquitin-Like-Specific Proteases

Small-Molecule Inhibitors and Probes for Ubiquitin- and Ubiquitin-Like-Specific Proteases

http://www.wikidata.org/entity/Q58214454

about

A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway Advances in the development of SUMO specific protease (SENP) inhibitors Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors Activity-Based Proteomic Profiling of Deubiquitinating Enzymes in Salmonella-Infected Macrophages Leads to Identification of Putative Function of UCH-L5 in Inflammasome Regulation Screen for ISG15-crossreactive deubiquitinases.Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes).Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes.Putting proteomics on target: activity-based profiling of ubiquitin and ubiquitin-like processing enzymes.Noncompetitive modulation of the proteasome by imidazoline scaffolds overcomes bortezomib resistance and delays MM tumor growth in vivo.It takes two to tango: Ubiquitin and SUMO in the DNA damage response.Evaluation of alpha,beta-unsaturated ketone-based probes for papain-family cysteine proteases.Allosteric activation of SENP1 by SUMO1 β-grasp domain involves a dock-and-coalesce mechanism.Identification and characterization of a new chemotype of noncovalent SENP inhibitors A modified epigenetics toolbox to study histone modifications on the nucleosome core.Chemical and semisynthetic approaches to study and target deubiquitinases.Monitoring Target Engagement of Deubiquitylating Enzymes Using Activity Probes: Past, Present, and Future.Activity-based probes for the ubiquitin conjugation-deconjugation machinery: new chemistries, new tools, and new insights.Computational Investigation of SENP:SUMO Protein-Protein Interaction for Structure Based Drug Design.Application of activity-based protein profiling to study enzyme function in adipocytes.Development of small molecule inhibitors and probes of human SUMO deconjugating proteases Dynamic imaging of protease activity with fluorescently quenched activity-based probes.Recognition-driven chemical labeling of endogenous proteins in multi-molecular crowding in live cells.

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Small-Molecule Inhibitors and Probes for Ubiquitin- and Ubiquitin-Like-Specific Proteases

http://www.wikidata.org/entity/Q58214454

description

im Januar 2005 veröffentlichter wissenschaftlicher Artikel

@de

scientific article published on 01 February 2005

@en

wetenschappelijk artikel

@nl

наукова стаття, опублікована в січні 2005

@uk

name

Small-Molecule Inhibitors and Probes for Ubiquitin- and Ubiquitin-Like-Specific Proteases

@en

Small-Molecule Inhibitors and Probes for Ubiquitin- and Ubiquitin-Like-Specific Proteases

@nl

type

label

Small-Molecule Inhibitors and Probes for Ubiquitin- and Ubiquitin-Like-Specific Proteases

@en

Small-Molecule Inhibitors and Probes for Ubiquitin- and Ubiquitin-Like-Specific Proteases

@nl

prefLabel

Small-Molecule Inhibitors and Probes for Ubiquitin- and Ubiquitin-Like-Specific Proteases

@en

Small-Molecule Inhibitors and Probes for Ubiquitin- and Ubiquitin-Like-Specific Proteases

@nl

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Small-molecule inhibitors and probes for ubiquitin- and ubiquitin-like-specific proteases

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Anna Borodovsky

http://www.w3.org/2001/XMLSchema#string

Brian G Hekking

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Emily S Venanzi

http://www.w3.org/2001/XMLSchema#string

Herman S Overkleeft

http://www.w3.org/2001/XMLSchema#string

Hidde L Ploegh

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Huib Ovaa

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Matthew S Bogyo

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P2860

A family of mammalian F-box proteins

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

Substrate binding and catalysis by ubiquitin C-terminal hydrolases: identification of two active site residues

BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

A new NEDD8-ligating system for cullin-4A

UBPY: a growth-regulated human ubiquitin isopeptidase.

An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells.

A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein

Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution

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287-291

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scholarly article

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10.1002/CBIC.200400236

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2

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6

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Benedikt M. Kessler

Wim J N Meester

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2005-02-01T00:00:00Z

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15651044

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molecular medicine

molecular biology