Small-Molecule Inhibitors and Probes for Ubiquitin- and Ubiquitin-Like-Specific Proteases
about
A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathwayAdvances in the development of SUMO specific protease (SENP) inhibitorsFunctional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitorsActivity-Based Proteomic Profiling of Deubiquitinating Enzymes in Salmonella-Infected Macrophages Leads to Identification of Putative Function of UCH-L5 in Inflammasome RegulationScreen for ISG15-crossreactive deubiquitinases.Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes).Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes.Putting proteomics on target: activity-based profiling of ubiquitin and ubiquitin-like processing enzymes.Noncompetitive modulation of the proteasome by imidazoline scaffolds overcomes bortezomib resistance and delays MM tumor growth in vivo.It takes two to tango: Ubiquitin and SUMO in the DNA damage response.Evaluation of alpha,beta-unsaturated ketone-based probes for papain-family cysteine proteases.Allosteric activation of SENP1 by SUMO1 β-grasp domain involves a dock-and-coalesce mechanism.Identification and characterization of a new chemotype of noncovalent SENP inhibitorsA modified epigenetics toolbox to study histone modifications on the nucleosome core.Chemical and semisynthetic approaches to study and target deubiquitinases.Monitoring Target Engagement of Deubiquitylating Enzymes Using Activity Probes: Past, Present, and Future.Activity-based probes for the ubiquitin conjugation-deconjugation machinery: new chemistries, new tools, and new insights.Computational Investigation of SENP:SUMO Protein-Protein Interaction for Structure Based Drug Design.Application of activity-based protein profiling to study enzyme function in adipocytes.Development of small molecule inhibitors and probes of human SUMO deconjugating proteasesDynamic imaging of protease activity with fluorescently quenched activity-based probes.Recognition-driven chemical labeling of endogenous proteins in multi-molecular crowding in live cells.
P2860
Q24315993-CFA2B0C5-1018-4B4F-9C48-B0521E9FDCEAQ26864235-8B733FDE-2507-4B06-92DA-518E5F9F0855Q27974595-D213E5A9-FB19-42BC-961F-7E90A4DA988AQ28547188-835BA83A-BF34-402D-AB45-02BE6F62F647Q33291767-129285A7-92AA-4A58-881E-B5BA3CDAE1ECQ33349184-DE56CE5B-233F-4ACF-B5F2-0EF0A949BEDFQ34300609-02CBF801-73DC-4F04-A354-16E9361F50E2Q36445577-7BC0BF27-50D5-4AB7-A958-3471BDB35A2AQ36691554-D1189EE2-11E2-4E5F-9D1A-29553A03407BQ36917433-95F773EC-ACB4-4F2A-9F90-E845C4C135A9Q37137274-C0E73CB9-ED8D-4986-991A-6F3419C25F39Q37270339-E0D2142A-97F0-4992-9E77-58CF789AB2E2Q37341772-BD3C5FCF-DCFC-478D-9AF5-21463C60403BQ37829707-805EA7CC-97C2-4A27-BD2E-2275BBF9FB4EQ38799376-3B2A4727-81D6-47B8-9084-EBA44FB56E1FQ38822748-70BB87C2-CFE3-4172-8EC6-210719DCD811Q39135148-E2CA5A3F-AEDF-4D1F-B6BC-BC2DAC3B89D5Q39535553-834DB81E-B041-453F-B1D9-8DD5313FC84CQ41874100-AAF0F04D-6D93-45C6-A132-708364247923Q42591560-75798398-6A89-4EEF-8DA8-F33D1518D06DQ42806191-8E5A0D32-60A0-448C-8813-0F2C03B1D7FAQ47449215-6F9773F2-C0A8-4A5D-99ED-6A6A5EAF4EA5
P2860
Small-Molecule Inhibitors and Probes for Ubiquitin- and Ubiquitin-Like-Specific Proteases
description
im Januar 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published on 01 February 2005
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в січні 2005
@uk
name
Small-Molecule Inhibitors and Probes for Ubiquitin- and Ubiquitin-Like-Specific Proteases
@en
Small-Molecule Inhibitors and Probes for Ubiquitin- and Ubiquitin-Like-Specific Proteases
@nl
type
label
Small-Molecule Inhibitors and Probes for Ubiquitin- and Ubiquitin-Like-Specific Proteases
@en
Small-Molecule Inhibitors and Probes for Ubiquitin- and Ubiquitin-Like-Specific Proteases
@nl
prefLabel
Small-Molecule Inhibitors and Probes for Ubiquitin- and Ubiquitin-Like-Specific Proteases
@en
Small-Molecule Inhibitors and Probes for Ubiquitin- and Ubiquitin-Like-Specific Proteases
@nl
P2093
P2860
P356
P1433
P1476
Small-molecule inhibitors and probes for ubiquitin- and ubiquitin-like-specific proteases
@en
P2093
Anna Borodovsky
Brian G Hekking
Emily S Venanzi
Herman S Overkleeft
Hidde L Ploegh
Matthew S Bogyo
P2860
P304
P356
10.1002/CBIC.200400236
P577
2005-02-01T00:00:00Z