GI Domain-mediated Association of the Eukaryotic Initiation Factor 2α Kinase GCN2 with Its Activator GCN1 Is Required for General Amino Acid Control in Budding Yeast - Wikidata - awgldk - TriplyDB

GI Domain-mediated Association of the Eukaryotic Initiation Factor 2α Kinase GCN2 with Its Activator GCN1 Is Required for General Amino Acid Control in Budding Yeast

GI Domain-mediated Association of the Eukaryotic Initiation Factor 2α Kinase GCN2 with Its Activator GCN1 Is Required for General Amino Acid Control in Budding Yeast

http://www.wikidata.org/entity/Q58416503

about

Cell growth control by stable Rbg2/Gir2 complex formation under amino acid starvation.Gcn1 and actin binding to Yih1: implications for activation of the eIF2 kinase GCN2.YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed.The highly conserved eukaryotic DRG factors are required for efficient translation in a manner redundant with the putative RNA helicase Slh1 Evidence that Yih1 resides in a complex with ribosomes.Saccharomyces cerevisiae Rbg1 protein and its binding partner Gir2 interact on Polyribosomes with Gcn1.Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells.IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation Recognition of a structural domain (RWDBD) in Gcn1 proteins that interacts with the RWD domain containing proteins.The yeast eIF4E-associated protein Eap1p attenuates GCN4 translation upon TOR-inactivation.Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress.The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.Differential activation of eIF2 kinases in response to cellular stresses in Schizosaccharomyces pombe.IMPACT is a GCN2 inhibitor that limits lifespan in Caenorhabditis elegans.A GCN2-like eukaryotic initiation factor 2 kinase increases the viability of extracellular Toxoplasma gondii parasites.The Gcn2 Regulator Yih1 Interacts with the Cyclin Dependent Kinase Cdc28 and Promotes Cell Cycle Progression through G2/M in Budding Yeast.Parkin and relatives: the RBR family of ubiquitin ligases.Solution structure of the RWD domain of the mouse GCN2 protein Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism.Characterization of the differentially methylated region of the Impact gene that exhibits Glires-specific imprinting.Comparative genomics of the RBR family, including the Parkinson's disease-related gene parkin and the genes of the ariadne subfamily.Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2.Differentially-expressed genes in Candida albicans exposed to ε-poly-L-lysine.Budding yeast GCN1 binds the GI domain to activate the eIF2alpha kinase GCN2.

P2860

Q27930224-5C622F49-A085-4AFB-9783-AC8420BB9E40 Q27931997-4464FE18-13ED-4861-BADC-7E79998CE087 Q27932122-59445520-B67E-4022-AEDA-3F1A30B20F71 Q27932287-652E4695-3A29-46F3-B17E-E0D00175B28C Q27935797-44922961-A47D-4234-AE20-903A53DCC237 Q27937295-2E153F16-DA62-4285-9208-FFB43E6941E9 Q27940265-A1C23131-61F7-44F6-85D7-A97EA81BE00C Q28507103-A314FDF6-8FB5-467D-8684-20EE5AE181B9 Q30852139-9039479E-6BDC-4445-A511-43BBFC662441 Q33285625-3F4E76C6-13BF-46E7-9A25-70B15AD2004E Q33905702-204867F3-5E71-4D85-B78D-0500A7800E58 Q34286263-A01CE67D-FEB9-4D3D-97CD-6092545C1349 Q34569312-B16FB37E-765F-4E89-968D-7D6D36157F4C Q34679101-B2B50473-CE1A-4F43-9B75-FAC86AD1CCD5 Q35530384-EEF496E7-B2E8-44B0-8B73-BAF179D39D30 Q35691820-582135D9-3EB6-454B-9EEA-DFA709F6D3FF Q35777606-DB0F074D-2572-48F3-B480-DF96F851EB6B Q36519167-A1A92F3B-98F2-4DC7-95F5-0579150F79E0 Q36830383-A87A6AF6-C5B6-4561-BCD4-04ECECAC8FE7 Q38475136-23C8A150-004B-4668-9A6D-99E4437684F5 Q42049727-B28A43F2-98F7-4E65-841F-6D8969EE8270 Q44391314-43E3F1F4-D812-48CA-B70B-1C8BD9963F35 Q45893467-CA0BBF43-E6FA-491F-B185-95E85A16ECAD Q52588189-FE7AE2D7-5E0C-4D1B-A728-E8A88C1ED027

P2860

GI Domain-mediated Association of the Eukaryotic Initiation Factor 2α Kinase GCN2 with Its Activator GCN1 Is Required for General Amino Acid Control in Budding Yeast

http://www.wikidata.org/entity/Q58416503

description

article publié dans la revue scientifique Journal of Biological Chemistry

@fr

im Juli 2000 veröffentlichter wissenschaftlicher Artikel

@de

scientific article published in Journal of Biological Chemistry

@en

wetenschappelijk artikel

@nl

наукова стаття, опублікована в травні 2000

@uk

name

GI Domain-mediated Association ...... Acid Control in Budding Yeast

@en

GI Domain-mediated Association ...... Acid Control in Budding Yeast

@nl

type

label

GI Domain-mediated Association ...... Acid Control in Budding Yeast

@en

GI Domain-mediated Association ...... Acid Control in Budding Yeast

@nl

prefLabel

GI Domain-mediated Association ...... Acid Control in Budding Yeast

@en

GI Domain-mediated Association ...... Acid Control in Budding Yeast

@nl

P1433

Q58416503-6A8AEBD4-142B-4141-8B61-1C8275B3ECBA

P1476

Q58416503-E4A70606-C792-4B8B-B01C-18F909B9577C

P2093

Q58416503-405F6F69-1635-41D6-81C2-BEAF3E79E063

Q58416503-D49A4C21-FFFC-44A7-BBA6-9976E05C54EA

P2860

Q58416503-173F3306-2357-4927-A3FD-26462A054C58

Q58416503-193C58A5-D06C-43DA-ADBA-23229A9EA406

Q58416503-1CB13E42-6637-48CC-84C9-AD32B26A2654

Q58416503-1F8E39FF-0D7B-4F28-B205-0768179248B7

Q58416503-239E116B-3553-489F-B794-570B26E0E0FD

Q58416503-2A2BCA0F-C96C-4C3F-A4FD-BD2BD256CBDB

Q58416503-47380785-C088-40EA-8383-FBFD15E51B45

Q58416503-81B98EA1-0F15-4AD7-BB4D-E25BE0778CD2

Q58416503-896C432F-3A5E-4B6E-A79E-10FC9B62F09C

Q58416503-8CDEFE98-CB7F-443C-8FF8-4A55253FEA36

P304

Q58416503-77E312C6-0E54-45B9-8539-702CB524838C

P31

Q58416503-EFD0211A-B9A8-4D3E-B412-00A1CAA95C7A

P356

Q58416503-D5B002C6-A14C-4929-81CE-9A4057D8FBF4

P407

Q58416503-A4FD2E5A-F661-4BC2-8696-2B0025DC675F

P433

Q58416503-D91DD01D-203B-4E19-A7B1-47493BEEA924

P478

Q58416503-E430D957-2904-4599-B159-2CE99A934F81

P50

Q58416503-A30031F9-EAF7-438A-A14D-BE192EA87CA8

P577

Q58416503-426FB443-5B32-461A-8805-1970A38DE8C6

P698

Q58416503-C04FFABF-23C8-427E-A077-BDF8C8D69B5E

P356

P1433

Journal of Biological Chemistry

P1476

GI domain-mediated association ...... acid control in budding yeast

@en

P2093

Kubota H

http://www.w3.org/2001/XMLSchema#string

Sakaki Y

http://www.w3.org/2001/XMLSchema#string

P2860

Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase

Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids

Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression.

Toward a protein-protein interaction map of the budding yeast: A comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins

Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.

GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2.

P304

20243-20246

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.C000262200

http://www.w3.org/2001/XMLSchema#string

P407

P433

27

http://www.w3.org/2001/XMLSchema#string

P478

275

http://www.w3.org/2001/XMLSchema#string

P50

P577

2000-07-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

10801780

http://www.w3.org/2001/XMLSchema#string