The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. - Wikidata - awgldk - TriplyDB

The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.

The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.

http://www.wikidata.org/entity/Q34286263

about

LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene Amino acids as regulators of gene expression Genome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2p Pulmonary capillary hemangiomatosis: a focus on the EIF2AK4 mutation in onset and pathogenesis Reviewing the Effects of L-Leucine Supplementation in the Regulation of Food Intake, Energy Balance, and Glucose Homeostasis Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR Nutrient-sensing mechanisms across evolution Central Amino Acid Sensing in the Control of Feeding Behavior Protein-dependent regulation of feeding and metabolism Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells FGF21 is an endocrine signal of protein restriction Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses Essential role of synoviolin in embryogenesis Heme-regulated eIF2alpha kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and beta-thalassemia IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth Drosophila larval to pupal switch under nutrient stress requires IP3R/Ca(2+) signalling in glutamatergic interneurons Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition by Blocking Autophagy Flux in Head and Neck Squamous Cell Carcinoma Cell Lines Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits.TGF-beta signaling controls embryo development in the parasitic flatworm Schistosoma mansoni.Arabidopsis eIF2alpha kinase GCN2 is essential for growth in stress conditions and is activated by wounding Amino acids regulate transgene expression in MDCK cells.Uridine affects liver protein glycosylation, insulin signaling, and heme biosynthesis.Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2alpha kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle.Expression profiling after activation of amino acid deprivation response in HepG2 human hepatoma cells eIF2alpha phosphorylation tips the balance to apoptosis during osmotic stress.Asparagine synthetase: a new potential biomarker in ovarian cancer.Inhibition of translation initiation by volatile anesthetics involves nutrient-sensitive GCN-independent and -dependent processes in yeast.Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation.Activation of the amino acid response modulates lineage specification during differentiation of murine embryonic stem cells.Hyperthermia induces the ER stress pathway.A mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK)-dependent transcriptional program controls activation of the early growth response 1 (EGR1) gene during amino acid limitation Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency.Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response.Induction of GADD34 is necessary for dsRNA-dependent interferon-β production and participates in the control of Chikungunya virus infection.

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P2860

The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.

http://www.wikidata.org/entity/Q34286263

description

2002 nî lūn-bûn

@nan

2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2002年の論文

@ja

2002年論文

@yue

2002年論文

@zh-hant

2002年論文

@zh-hk

2002年論文

@zh-mo

2002年論文

@zh-tw

2002年论文

@wuu

name

The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.

@ast

The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.

@en

The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.

@nl

type

label

The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.

@ast

The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.

@en

The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.

@nl

prefLabel

The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.

@ast

The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.

@en

The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.

@nl

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P356

MCB.22.19.6681-6688.2002

P1433

Molecular and Cellular Biology

P1476

The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.

@en

P2093

Barbara C McGrath

http://www.w3.org/2001/XMLSchema#string

DeAnne S Olsen

http://www.w3.org/2001/XMLSchema#string

Douglas R Cavener

http://www.w3.org/2001/XMLSchema#string

Jamie Reinert

http://www.w3.org/2001/XMLSchema#string

Krishna M Vattem

http://www.w3.org/2001/XMLSchema#string

Leonard S Jefferson

http://www.w3.org/2001/XMLSchema#string

Li Lei

http://www.w3.org/2001/XMLSchema#string

Peichuan Zhang

http://www.w3.org/2001/XMLSchema#string

Ronald C Wek

http://www.w3.org/2001/XMLSchema#string

Sangeeta Gill

http://www.w3.org/2001/XMLSchema#string

P2860

Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase

Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress

Isolation of the gene encoding the Drosophila melanogaster homolog of the Saccharomyces cerevisiae GCN2 eIF-2alpha kinase

A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha

Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation

The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids

Multiple upstream AUG codons mediate translational control of GCN4.

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast.

Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.

Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain.

P304

6681-6688

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scholarly article

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10.1128/MCB.22.19.6681-6688.2002

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19

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12215525

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134046

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