about
The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase IIFunctional effects of PTPN11 (SHP2) mutations causing LEOPARD syndrome on epidermal growth factor-induced phosphoinositide 3-kinase/AKT/glycogen synthase kinase 3beta signalingHow do Shp2 mutations that oppositely influence its biochemical activity result in syndromes with overlapping symptoms?A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor.LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesityPhosphoinositide 3-kinases in lysophosphatidic acid signaling: regulation and cross-talk with the Ras/mitogen-activated protein kinase pathway.Gab1, SHP-2 and other novel regulators of Ras: targets for anticancer drug discovery?Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature.The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway.SHP2 sails from physiology to pathology.Signal strength dictates phosphoinositide 3-kinase contribution to Ras/extracellular signal-regulated kinase 1 and 2 activation via differential Gab1/Shp2 recruitment: consequences for resistance to epidermal growth factor receptor inhibition.Growth patterns of patients with Noonan syndrome: correlation with age and genotype.An epidermal growth factor receptor/Gab1 signaling pathway is required for activation of phosphoinositide 3-kinase by lysophosphatidic acid.A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid.Modulation of phosphoinositide 3-kinase activation by cholesterol level suggests a novel positive role for lipid rafts in lysophosphatidic acid signalling.[Lysophospholipids and cancer: current status and perspectives][New molecular mechanisms of growth hormone insensitivity].Noonan syndrome: an update on growth and development.Noonan syndrome males display Sertoli cell-specific primary testicular insufficiencyThe Adaptor Protein Gab1 Couples the Stimulation of Vascular Endothelial Growth Factor Receptor-2 to the Activation of Phosphoinositide 3-KinaseSporadic human renal tumors display frequent allelic imbalances and novel mutations of the HRPT2 geneNoonan syndrome-causing SHP2 mutants impair ERK-dependent chondrocyte differentiation during endochondral bone growthThe RASopathy Family: Consequences of Germline Activation of the RAS/MAPK PathwayCatalytic dysregulation of SHP2 leading to Noonan syndromes affects platelet signaling and functions
P50
Q24304135-DC8CE436-EE40-4BDB-AEDD-A0C0DF12F428Q24304242-80F6FE51-9961-4C59-B5ED-ADA332B5C19FQ28299048-774D5CA2-4DAD-4A98-821F-25A9F349CECEQ33929512-CFED1577-C541-4631-A872-BC4AEDD6C945Q34409247-4D14E2CD-7B25-43C0-89F0-B0FEA81BBF18Q34691469-06F642DB-3B23-44F8-AA76-FA8E91C2F86AQ35137561-85C96C21-EA03-4891-8726-4C9469860C86Q35837138-6D114BD1-E24B-40F4-BA62-29C0D9C4B305Q36997418-1D7E63FE-B025-40C9-8E89-F8CC0D8B7DB2Q38580957-3A473F08-486F-4A31-848B-C2B80DD22955Q40048491-F3F28B87-4355-4AC6-8A6F-8307ABD73A06Q40894451-DD39AFE9-5D2E-4E9A-B6F1-CB51EC44E7CAQ40919265-F20C8D8B-B9E1-4350-A7DC-72F8915F6316Q42817181-459B18EE-B455-418D-A777-161CF7D5510AQ44277944-75B554AD-975E-43CF-9CA3-B7352AA24326Q45202785-C93FE1C3-EA9A-4AC7-8EA2-890FEA2F0B36Q46799175-5363CFAA-5014-482A-B041-114BBBD6D7CCQ47421391-1A035D5E-1451-4FE7-BA11-FAE856493A98Q57486126-0D3A8F36-BA3F-4C1A-B978-1211E5695DE6Q64355677-15933653-7921-4612-A7C9-ADB095AE9899Q79387201-45B4078E-2A2C-4EF6-B86D-5AA33B5A6E33Q88371226-26192549-B17B-4798-90B3-DA6572D6CD27Q89165738-A66E15B3-6050-4A88-8898-705DDD1B8918Q90338517-8A574998-68A2-4EDA-8C69-CF8AFA5CA6B8
P50
description
researcher ORCID ID = 0000-0002-2412-9840
@en
wetenschapper
@nl
name
Armelle Yart
@ast
Armelle Yart
@en
Armelle Yart
@es
Armelle Yart
@nl
type
label
Armelle Yart
@ast
Armelle Yart
@en
Armelle Yart
@es
Armelle Yart
@nl
prefLabel
Armelle Yart
@ast
Armelle Yart
@en
Armelle Yart
@es
Armelle Yart
@nl
P106
P31
P496
0000-0002-2412-9840