A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid.
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A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activationA pharmacological map of the PI3-K family defines a role for p110alpha in insulin signalingTruncation of the A1 adenosine receptor reveals distinct roles of the membrane-proximal carboxyl terminus in receptor folding and G protein couplingP2Y12 receptor stimulation inhibits beta-adrenergic receptor-induced differentiation by reversing the cyclic AMP-dependent inhibition of protein kinase BIdentification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma.Inhibitory odorant signaling in Mammalian olfactory receptor neurons.Relaxin stimulates multiple signaling pathways: activation of cAMP, PI3K, and PKCzeta in THP-1 cells.Clinical development of phosphatidylinositol 3-kinase inhibitors for cancer treatmentA3 adenosine and CB1 receptors activate a PKC-sensitive Cl- current in human nonpigmented ciliary epithelial cells via a G beta gamma-coupled MAPK signaling pathway.Simvastatin inhibits Staphylococcus aureus host cell invasion through modulation of isoprenoid intermediates.Role of PI4K and PI3K-AKT in ERK1/2 activation by GnRH in the pituitary gonadotropes.The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.Phosphoinositide 3-OH kinase p85alpha and p110beta are essential for androgen receptor transactivation and tumor progression in prostate cancers.Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis.P2Y12 receptor: platelet thrombus formation and medical interventions.The secret life of kinases: functions beyond catalysisLysophosphatidic acid-stimulated phosphorylation of PKD2 is mediated by PI3K p110β and PKCδ in myoblasts.Signal strength dictates phosphoinositide 3-kinase contribution to Ras/extracellular signal-regulated kinase 1 and 2 activation via differential Gab1/Shp2 recruitment: consequences for resistance to epidermal growth factor receptor inhibition.Vasoactive intestinal peptide induces neuroendocrine differentiation in the LNCaP prostate cancer cell line through PKA, ERK, and PI3K.Genetic down-regulation of phosphoinositide 3-kinase by bikunin correlates with suppression of invasion and metastasis in human ovarian cancer HRA cells.Specific role for p85/p110beta in GTP-binding-protein-mediated activation of Akt.Phosphoinositide-3-kinases p110α and p110β mediate S phase entry in astroglial cells in the marginal zone of rat neocortex.Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement.Integration of P2Y receptor-activated signal transduction pathways in G protein-dependent signalling networksRas activation in response to lysophosphatidic acid requires a permissive input from the epidermal growth factor receptorA selective role for phosphatidylinositol 3,4,5-trisphosphate in the Gi-dependent activation of platelet Rap1B.Modulation of phosphoinositide 3-kinase activation by cholesterol level suggests a novel positive role for lipid rafts in lysophosphatidic acid signalling.sst2 Somatostatin receptor inhibits cell proliferation through Ras-, Rap1-, and B-Raf-dependent ERK2 activation.Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-beta in human bronchial epithelial cells.Gbetagamma subunits stimulate p21-activated kinase 1 (PAK1) through activation of PI3-kinase and Akt but act independently of Rac1/Cdc42.Gi-dependent and -independent mechanisms downstream of the P2Y12 ADP-receptor.LPA2 receptor mediates mitogenic signals in human colon cancer cells.BCR-ABL regulates phosphatidylinositol 3-kinase-p110gamma transcription and activation and is required for proliferation and drug resistance.Development of highly sensitive cell-based AKT kinase ELISA for monitoring PI3K beta activity and compound efficacy.
P2860
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P2860
A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
A function for phosphoinositid ...... onse to lysophosphatidic acid.
@en
A function for phosphoinositid ...... onse to lysophosphatidic acid.
@nl
type
label
A function for phosphoinositid ...... onse to lysophosphatidic acid.
@en
A function for phosphoinositid ...... onse to lysophosphatidic acid.
@nl
prefLabel
A function for phosphoinositid ...... onse to lysophosphatidic acid.
@en
A function for phosphoinositid ...... onse to lysophosphatidic acid.
@nl
P2093
P2860
P356
P1476
A function for phosphoinositid ...... ponse to lysophosphatidic acid
@en
P2093
Hugues Chap
Nicholas Tonks
Patrick Mayeux
Patrick Raynal
Reinhard Wetzker
Serge Roche
P2860
P304
21167-21178
P356
10.1074/JBC.M110411200
P407
P577
2002-03-26T00:00:00Z