about
DNAJC13 mutations in Parkinson diseaseAcute and chronic antiparkinsonian effects of the novel nociceptin/orphanin FQ receptor antagonist NiK-21273 in comparison with SB-612111.Memory and synaptic deficits in Hip14/DHHC17 knockout mice.Insights from late-onset familial parkinsonism on the pathogenesis of idiopathic Parkinson's disease.CADPS2 gene expression is oppositely regulated by LRRK2 and alpha-synuclein.LRRK2 mouse models: dissecting the behavior, striatal neurochemistry and neurophysiology of PD pathogenesis.Elevated levels of alpha-synuclein blunt cellular signal transduction downstream of Gq protein-coupled receptors.Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release.Nanoparticulate lipid dispersions for bromocriptine delivery: characterization and in vivo study.Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice.Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in miceLRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory.Stimulation of delta opioid receptors located in substantia nigra reticulata but not globus pallidus or striatum restores motor activity in 6-hydroxydopamine lesioned rats: new insights into the role of delta receptors in parkinsonism.Stimulation of δ opioid receptor and blockade of nociceptin/orphanin FQ receptor synergistically attenuate parkinsonism.Behavioral deficits and striatal DA signaling in LRRK2 p.G2019S transgenic rats: a multimodal investigation including PET neuroimaging.Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's disease VPS35 mutation p.D620N.A new hypothesis for Parkinson's disease pathogenesis: GTPase-p38 MAPK signaling and autophagy as convergence points of etiology and genomicsDopamine–nociceptin/orphanin FQ interactions in the substantia nigra reticulata of hemiparkinsonian rats: Involvement of D2/D3 receptors and impact on nigro-thalamic neurons and motor activityKinase inhibition of G2019S-LRRK2 enhances autolysosome formation and function to reduce endogenous alpha-synuclein intracellular inclusions
P50
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P50
description
onderzoeker
@nl
researcher ORCID ID = 0000-0002-0300-6796
@en
name
Mattia Volta
@ast
Mattia Volta
@en
Mattia Volta
@es
Mattia Volta
@nl
type
label
Mattia Volta
@ast
Mattia Volta
@en
Mattia Volta
@es
Mattia Volta
@nl
prefLabel
Mattia Volta
@ast
Mattia Volta
@en
Mattia Volta
@es
Mattia Volta
@nl
P106
P1153
25655476600
P21
P2798
P31
P496
0000-0002-0300-6796