LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory.
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Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in miceLeucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brainBehavioural abnormalities in a novel mouse model for Silver Russell Syndrome.Role of LRRK2 in the regulation of dopamine receptor traffickingThe Parkinson's Disease-Associated Mutation LRRK2-G2019S Impairs Synaptic Plasticity in Mouse Hippocampus.Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression.LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit functionAltered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2-G2019S MutationG2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons.Changes in functional organization and white matter integrity in the connectome in Parkinson's disease.Endogenous Leucine-Rich Repeat Kinase 2 Slows Synaptic Vesicle Recycling in Striatal Neurons.Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice.Overexpression of Parkinson's Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein PathologyReview: Parkinson's disease: from synaptic loss to connectome dysfunction.Human LRRK2 G2019S mutation represses post-synaptic protein PSD95 and causes cognitive impairment in transgenic miceEarly synaptic dysfunction in Parkinson's disease: Insights from animal models.Epigenetic mechanisms in neurogenesis.Models of LRRK2-Associated Parkinson's Disease.Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in miceSynapses in neurodegenerative diseases.Mitochondria: A Common Target for Genetic Mutations and Environmental Toxicants in Parkinson's Disease.PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons.Mechanisms of Mutant LRRK2 Neurodegeneration.Impaired intracortical transmission in G2019S leucine rich-repeat kinase Parkinson patients.Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice.Dopamine D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson's disease.
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P2860
LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
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2014年學術文章
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2014年學術文章
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name
LRRK2 overexpression alters gl ...... on, motor activity and memory.
@en
LRRK2 overexpression alters gl ...... on, motor activity and memory.
@nl
type
label
LRRK2 overexpression alters gl ...... on, motor activity and memory.
@en
LRRK2 overexpression alters gl ...... on, motor activity and memory.
@nl
prefLabel
LRRK2 overexpression alters gl ...... on, motor activity and memory.
@en
LRRK2 overexpression alters gl ...... on, motor activity and memory.
@nl
P2860
P50
P921
P356
P1476
LRRK2 overexpression alters gl ...... on, motor activity and memory.
@en
P2860
P304
P356
10.1093/HMG/DDU543
P4011
d7c8de79306883f1be34a56ee3a734c21371dc12
P407
P50
P577
2014-10-24T00:00:00Z