about
A palmitoylation switch mechanism regulates Rac1 function and membrane organization.Molecular Mechanisms Underlying Peritoneal EMT and FibrosisCaveolae - mechanosensitive membrane invaginations linked to actin filamentsActivation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignmentInhibition of transforming growth factor-activated kinase 1 (TAK1) blocks and reverses epithelial to mesenchymal transition of mesothelial cellsPhospho-caveolin-1 mediates integrin-regulated membrane domain internalization.Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression.Physical principles of membrane remodelling during cell mechanoadaptationThe molecular adapter SLP-76 relays signals from platelet integrin alphaIIbbeta3 to the actin cytoskeleton.Caveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17.Integrin signaling and lipid rafts.Critical role of CAV1/caveolin-1 in cell stress responses in human breast cancer cells via modulation of lysosomal function and autophagy.Characterization of Novel Molecular Mechanisms Favoring Rac1 Membrane Translocation.Caveolae internalization regulates integrin-dependent signaling pathways.Intracellular trafficking of raft/caveolae domains: insights from integrin signaling.Interplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice.Caveolae as plasma membrane sensors, protectors and organizers.Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation.Cell-based fuzzy metrics enhance high-content screening (HCS) assay robustness.Phosphorylation of filamin A regulates chemokine receptor CCR2 recycling.Epithelial-to-mesenchymal transition of peritoneal mesothelial cells is regulated by an ERK/NF-kappaB/Snail1 pathway.A novel high-content analysis tool reveals Rab8-driven cytoskeletal reorganization through Rho GTPases, calpain and MT1-MMP.Prevention of in vitro neutrophil-endothelial attachment through shedding of L-selectin by nonsteroidal antiinflammatory drugs.Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK.A Novel Systems-Biology Algorithm for the Analysis of Coordinated Protein Responses Using Quantitative ProteomicsHematopoietic cell-type-dependent regulation of leukocyte integrin functional activity: CD11b and CD11c expression inhibits LFA-1-dependent aggregation of differentiated U937 cells.Induction of tyrosine phosphorylation during ICAM-3 and LFA-1-mediated intercellular adhesion, and its regulation by the CD45 tyrosine phosphatase.Caveolin-1 deficiency induces a MEK-ERK1/2-Snail-1-dependent epithelial-mesenchymal transition and fibrosis during peritoneal dialysisThe Dioxin receptor modulates Caveolin-1 mobilization during directional migration: role of cholesterol.The absence of caveolin-1 increases proliferation and anchorage- independent growth by a Rac-dependent, Erk-independent mechanism.Distribution of ICAM-3-bearing cells in normal human tissues. Expression of a novel counter-receptor for LFA-1 in epidermal Langerhans cells.p38 maintains E-cadherin expression by modulating TAK1-NF-kappa B during epithelial-to-mesenchymal transition.Roles of microtubule dynamics and small GTPase Rac in endothelial cell migration and lamellipodium formation under flow.Distinct functions of Vav1 in JNK1 activation in Jurkat T cells versus non-haematopoietic cells.Localized cdc42 activation, detected using a novel assay, mediates microtubule organizing center positioning in endothelial cells in response to fluid shear stress.AKT-mTOR signaling modulates the dynamics of IRE1 RNAse activity by regulating ER-mitochondria contacts.Protein Localization at Mitochondria-ER Contact Sites in Basal and Stress Conditions.The chemokine SDF-1alpha triggers a chemotactic response and induces cell polarization in human B lymphocytes.Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance.ITGB1-dependent upregulation of Caveolin-1 switches TGFβ signalling from tumour-suppressive to oncogenic in prostate cancer.
P50
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P50
description
onderzoeker
@nl
researcher ORCID ID = 0000-0001-9077-391X
@en
name
Miguel A Del Pozo
@ast
Miguel A Del Pozo
@en
Miguel A Del Pozo
@es
Miguel A Del Pozo
@nl
type
label
Miguel A Del Pozo
@ast
Miguel A Del Pozo
@en
Miguel A Del Pozo
@es
Miguel A Del Pozo
@nl
prefLabel
Miguel A Del Pozo
@ast
Miguel A Del Pozo
@en
Miguel A Del Pozo
@es
Miguel A Del Pozo
@nl
P106
P21
P31
P496
0000-0001-9077-391X