Localized cdc42 activation, detected using a novel assay, mediates microtubule organizing center positioning in endothelial cells in response to fluid shear stress.
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beta-Dystroglycan modulates the interplay between actin and microtubules in human-adhered plateletsNesprin-3 regulates endothelial cell morphology, perinuclear cytoskeletal architecture, and flow-induced polarizationMolecular mechanisms controlling vascular lumen formation in three-dimensional extracellular matricesCaveolin-1-enhanced motility and focal adhesion turnover require tyrosine-14 but not accumulation to the rear in metastatic cancer cellsErbB2-dependent chemotaxis requires microtubule capture and stabilization coordinated by distinct signaling pathways.Collective cell migration drives morphogenesis of the kidney nephronA new genetically encoded single-chain biosensor for Cdc42 based on FRET, useful for live-cell imagingNuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migrationRear polarization of the microtubule-organizing center in neointimal smooth muscle cells depends on PKCα, ARPC5, and RHAMMAPC nuclear membrane association and microtubule polarityFlow-dependent cellular mechanotransduction in atherosclerosis.JNK2 promotes endothelial cell alignment under flowMatrix-specific protein kinase A signaling regulates p21-activated kinase activation by flow in endothelial cellsFocal adhesion kinase modulates activation of NF-kappaB by flow in endothelial cells.Molecular control of cytoskeletal mechanics by hemodynamic forces.Micropatterned structural control suppresses mechanotaxis of endothelial cellsMechanotransduction in vascular physiology and atherogenesis.Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesis.Arterial shear stress regulates endothelial cell-directed migration, polarity, and morphology in confluent monolayers.Polarity reveals intrinsic cell chiralityCdc42 mediates nucleus movement and MTOC polarization in Swiss 3T3 fibroblasts under mechanical shear stressOrientation of endothelial cell division is regulated by VEGF signaling during blood vessel formationCell polarity triggered by cell-cell adhesion via E-cadherin.Shear-induced endothelial cell-cell junction inclination.The nucleus of endothelial cell as a sensor of blood flow directionRhoA and membrane fluidity mediates the spatially polarized Src/FAK activation in response to shear stress.Formin-mediated actin polymerization at cell-cell junctions stabilizes E-cadherin and maintains monolayer integrity during wound repair.Directing cell migration with asymmetric micropatterns.Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling.POPX2 phosphatase regulates cell polarity and centrosome placement.Cellular responses to extracellular guidance cuesThe shear stress-induced transcription factor KLF2 affects dynamics and angiopoietin-2 content of Weibel-Palade bodies.Cdc42-mediated inhibition of GSK-3β improves angio-architecture and lumen formation during VEGF-driven pathological angiogenesis.Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblasts.The formin mDia regulates GSK3beta through novel PKCs to promote microtubule stabilization but not MTOC reorientation in migrating fibroblasts.The role of Rho GTPase proteins in CNS neuronal migration.The Cdc42 Effector Kinase PAK4 Localizes to Cell-Cell Junctions and Contributes to Establishing Cell Polarity.SMRT analysis of MTOC and nuclear positioning reveals the role of EB1 and LIC1 in single-cell polarization.Flow mechanotransduction regulates traction forces, intercellular forces, and adherens junctionsCentrosomal AKAP350 and CIP4 act in concert to define the polarized localization of the centrosome and Golgi in migratory cells
P2860
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P2860
Localized cdc42 activation, detected using a novel assay, mediates microtubule organizing center positioning in endothelial cells in response to fluid shear stress.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Localized cdc42 activation, de ...... esponse to fluid shear stress.
@en
Localized cdc42 activation, de ...... esponse to fluid shear stress.
@nl
type
label
Localized cdc42 activation, de ...... esponse to fluid shear stress.
@en
Localized cdc42 activation, de ...... esponse to fluid shear stress.
@nl
prefLabel
Localized cdc42 activation, de ...... esponse to fluid shear stress.
@en
Localized cdc42 activation, de ...... esponse to fluid shear stress.
@nl
P2860
P356
P1476
Localized cdc42 activation, de ...... response to fluid shear stress
@en
P2093
Eleni Tzima
William B Kiosses
P2860
P304
31020-31023
P356
10.1074/JBC.M301179200
P407
P577
2003-05-16T00:00:00Z