Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling

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Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling

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im August 2018 veröffentlichter wissenschaftlicher Artikel

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scientific article published on 29 August 2018

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wetenschappelijk artikel

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наукова стаття, опублікована в серпні 2018

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Presenilin 1 deficiency suppre ...... independent ERK/CREB signaling

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Presenilin 1 deficiency suppre ...... independent ERK/CREB signaling

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Presenilin 1 deficiency suppre ...... independent ERK/CREB signaling

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Presenilin 1 deficiency suppre ...... independent ERK/CREB signaling

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Presenilin 1 deficiency suppre ...... independent ERK/CREB signaling

@en

Presenilin 1 deficiency suppre ...... independent ERK/CREB signaling

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P1476

Presenilin 1 deficiency suppre ...... independent ERK/CREB signaling

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Cheong-Meng Chong

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Dajiang Qin

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Ke Zhang

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Minjing Ke

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Nana Ai

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Wei Ge

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Yuan Tan

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Zhijian Huang

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P2860

Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Generalized potential of adult neural stem cells

Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces

Development and applications of CRISPR-Cas9 for genome engineering.

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

Enumeration of neural stem and progenitor cells in the neural colony-forming cell assay

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons

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879

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scholarly article

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10.1038/S41419-018-0945-7

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English

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Jiahong Lu

Huanxing Su

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2018-08-29T00:00:00Z

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30158533

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immunology

cancer research

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6115391

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