Parkin is a disease modifier in the mutant SOD1 mouse model of ALS

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Parkin is a disease modifier in the mutant SOD1 mouse model of ALS

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scientific article published on 01 October 2018

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wetenschappelijk artikel

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наукова стаття, опублікована в жовтні 2018

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Parkin is a disease modifier in the mutant SOD1 mouse model of ALS

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Parkin is a disease modifier in the mutant SOD1 mouse model of ALS

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Parkin is a disease modifier in the mutant SOD1 mouse model of ALS

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Parkin is a disease modifier in the mutant SOD1 mouse model of ALS

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Parkin is a disease modifier in the mutant SOD1 mouse model of ALS

@en

Parkin is a disease modifier in the mutant SOD1 mouse model of ALS

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P1476

Parkin is a disease modifier in the mutant SOD1 mouse model of ALS

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P2093

Csaba Konrad

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Dazhi Zhao

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Gloria M Palomo

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Hibiki Kawamata

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Michelle Kim

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Teresa A Milner

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Veronica Granatiero

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P2860

Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator

PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease

Ubiquitin is phosphorylated by PINK1 to activate parkin

PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility

Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1

A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation

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e8888

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scholarly article

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10.15252/EMMM.201808888

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English

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P478

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Andrea J Arreguin

Giovanni Manfredi

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2018-10-01T00:00:00Z

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30126943

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P921

amyotrophic lateral sclerosis

molecular medicine

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6180298

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