Chaperonin 60 sustains osteoblast autophagy and counteracts glucocorticoid aggravation of osteoporosis by chaperoning RPTOR

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Chaperonin 60 sustains osteoblast autophagy and counteracts glucocorticoid aggravation of osteoporosis by chaperoning RPTOR

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im September 2018 veröffentlichter wissenschaftlicher Artikel

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wetenschappelijk artikel

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наукова стаття, опублікована у вересні 2018

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Chaperonin 60 sustains osteobl ...... eoporosis by chaperoning RPTOR

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Chaperonin 60 sustains osteobl ...... eoporosis by chaperoning RPTOR

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Chaperonin 60 sustains osteobl ...... eoporosis by chaperoning RPTOR

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Chaperonin 60 sustains osteobl ...... eoporosis by chaperoning RPTOR

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Chaperonin 60 sustains osteobl ...... eoporosis by chaperoning RPTOR

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Chaperonin 60 sustains osteobl ...... eoporosis by chaperoning RPTOR

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Chaperonin 60 sustains osteobl ...... eoporosis by chaperoning RPTOR

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Chung-Wen Kuo

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Feng-Sheng Wang

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Huei-Jing Ke

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Jih-Yang Ko

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Shin-Long Wu

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Wei-Shiung Lian

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Yu-Shan Chen

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FUS Interacts with HSP60 to Promote Mitochondrial Damage

Heat shock protein 60 protects skeletal tissue against glucocorticoid-induced bone mass loss by regulating osteoblast survival

Autophagy in human health and disease

Hyperglycemia diverts dividing osteoblastic precursor cells to an adipogenic pathway and induces synthesis of a hyaluronan matrix that is adhesive for monocytes

NLRP3 promotes autophagy of urate crystals phagocytized by human osteoblasts.

Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IκB kinase α (IKKα).

mTORC1 signaling controls mammalian skeletal growth through stimulation of protein synthesis.

Prevention of glucocorticoid induced-apoptosis of osteoblasts and osteocytes by protecting against endoplasmic reticulum (ER) stress in vitro and in vivo in female mice.

Crystal structure of the human mitochondrial chaperonin symmetrical football complex.

Autophagy in osteoblasts is involved in mineralization and bone homeostasis.

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938

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scholarly article

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10.1038/S41419-018-0970-6

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English

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2018-09-17T00:00:00Z

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30224697

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6141469

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