Depletion of CD8+ T cells increases susceptibility and reverses vaccine-induced immunity in mice infected with Trypanosoma cruzi
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Evasion of the Immune Response by Trypanosoma cruzi during Acute InfectionCD8+ T cells in Trypanosoma cruzi infectionCurrent understanding of immunity to Trypanosoma cruzi infection and pathogenesis of Chagas diseaseDNA-Based immunization with Trypanosoma cruzi complement regulatory protein elicits complement lytic antibodies and confers protection against Trypanosoma cruzi infectionFurther characterization of protective Trypanosoma cruzi-specific CD4+ T-cell clones: T helper type 1-like phenotype and reactivity with shed trypomastigote antigens.Specific humoral immunity versus polyclonal B cell activation in Trypanosoma cruzi infection of susceptible and resistant mice.Vaccination with trypomastigote surface antigen 1-encoding plasmid DNA confers protection against lethal Trypanosoma cruzi infection.Trypanosoma cruzi subverts host cell sialylation and may compromise antigen-specific CD8+ T cell responses.Experimental infection with Trypanosoma cruzi increases the population of CD8(+), but not CD4(+), immunoglobulin G Fc receptor-positive T lymphocytes.Generation of Trypanosoma cruzi-specific CD8+ T-cell immunity is unaffected by the absence of type I interferon signaling.Influence of acute-phase parasite load on pathology, parasitism, and activation of the immune system at the late chronic phase of Chagas' disease.Involvement of CD4(+) Th1 cells in systemic immunity protective against primary and secondary challenges with Trypanosoma cruzi.DNA immunization with Trypanosoma cruzi HSP70 fused to the KMP11 protein elicits a cytotoxic and humoral immune response against the antigen and leads to protection.Regulation of CD8+ T cell responses to infection with parasitic protozoa.Immune responses against a single CD8+-T-cell epitope induced by virus vector vaccination can successfully control Trypanosoma cruzi infectionCruzipain induces both mucosal and systemic protection against Trypanosoma cruzi in mice.Coadministration of an interleukin-12 gene and a Trypanosoma cruzi gene improves vaccine efficacyPerpetual expression of PAMPs necessary for optimal immune control and clearance of a persistent pathogenContribution of NK, NK T, gamma delta T, and alpha beta T cells to the gamma interferon response required for liver protection against Trypanosoma cruziActivation of natural killer T cells by alpha-galactosylceramide impairs DNA vaccine-induced protective immunity against Trypanosoma cruzi.Inducible nitric oxide synthase is not essential for control of Trypanosoma cruzi infection in mice.Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease.Critical contribution of CD28-CD80/CD86 costimulatory pathway to protection from Trypanosoma cruzi infection.Oral exposure to Trypanosoma cruzi elicits a systemic CD8⁺ T cell response and protection against heterotopic challengePure paraflagellar rod protein protects mice against Trypanosoma cruzi infectionChagas' disease.Interleukin-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotesInterleukin-12-mediated resistance to Trypanosoma cruzi is dependent on tumor necrosis factor alpha and gamma interferon.Evidence for a protective role of tumor necrosis factor in the acute phase of Trypanosoma cruzi infection in mice.B-Cell Response during Protozoan Parasite InfectionsPivotal role of interleukin-12 and interferon-gamma axis in controlling tissue parasitism and inflammation in the heart and central nervous system during Trypanosoma cruzi infection.Depletion of T-cell subpopulations results in exacerbation of myocarditis and parasitism in experimental Chagas' disease.Promiscuous Recognition of a Trypanosoma cruzi CD8+ T Cell Epitope among HLA-A2, HLA-A24 and HLA-A1 Supertypes in Chagasic Patients.Costimulatory Effects of an Immunodominant Parasite Antigen Paradoxically Prevent Induction of Optimal CD8 T Cell Protective Immunity.Intrapulmonary growth and dissemination of an avirulent strain of Cryptococcus neoformans in mice depleted of CD4+ or CD8+ T cellsAn immunoinformatic approach for identification of Trypanosoma cruzi HLA-A2-restricted CD8(+) T cell epitopes.Mucosal and systemic T cell response in mice intragastrically infected with Neospora caninum tachyzoites.A therapeutic nanoparticle vaccine against Trypanosoma cruzi in a BALB/c mouse model of Chagas disease.CD8+ T cells specific for immunodominant trans-sialidase epitopes contribute to control of Trypanosoma cruzi infection but are not required for resistance.Human infection with Trypanosoma cruzi induces parasite antigen-specific cytotoxic T lymphocyte responses.
P2860
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P2860
Depletion of CD8+ T cells increases susceptibility and reverses vaccine-induced immunity in mice infected with Trypanosoma cruzi
description
im Januar 1990 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в січні 1990
@uk
name
Depletion of CD8+ T cells incr ...... nfected with Trypanosoma cruzi
@en
Depletion of CD8+ T cells incr ...... nfected with Trypanosoma cruzi
@nl
type
label
Depletion of CD8+ T cells incr ...... nfected with Trypanosoma cruzi
@en
Depletion of CD8+ T cells incr ...... nfected with Trypanosoma cruzi
@nl
prefLabel
Depletion of CD8+ T cells incr ...... nfected with Trypanosoma cruzi
@en
Depletion of CD8+ T cells incr ...... nfected with Trypanosoma cruzi
@nl
P1476
Depletion of CD8+ T cells incr ...... nfected with Trypanosoma cruzi
@en
P2093
R L Tarleton
P304
P407
P577
1990-01-15T00:00:00Z