about
The transcriptional co-repressor myeloid translocation gene 16 inhibits glycolysis and stimulates mitochondrial respirationPyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells.Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion.RX871024 reduces NO production but does not protect against pancreatic beta-cell death induced by proinflammatory cytokines.Characterization of stimulus-secretion coupling in the human pancreatic EndoC-βH1 beta cell line.Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion.Chronic high glucose and pyruvate levels differentially affect mitochondrial bioenergetics and fuel-stimulated insulin secretion from clonal INS-1 832/13 cells.Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal β-cell lines.A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes.Monomeric G-protein, Rhes, is not an imidazoline-regulated protein in pancreatic beta-cells.Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes.Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release.Unique and Shared Metabolic Regulation in Clonal β-Cells and Primary Islets Derived From Rat Revealed by Metabolomics Analysis.Novel Formulations of C-Peptide with Long-Acting Therapeutic Potential for Treatment of Diabetic ComplicationspH-Sensitive Chitosan-Heparin Nanoparticles for Effective Delivery of Genetic Drugs into Epithelial CellsPhotosensitive Poly-l-lysine/Heparin Interpolyelectrolyte Complexes for Delivery of Genetic Drugs
P50
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P50
description
researcher ORCID ID = 0000-0002-3717-0471
@en
wetenschapper
@nl
name
Vladimir V Sharoyko
@ast
Vladimir V Sharoyko
@en
Vladimir V Sharoyko
@es
Vladimir V Sharoyko
@nl
type
label
Vladimir V Sharoyko
@ast
Vladimir V Sharoyko
@en
Vladimir V Sharoyko
@es
Vladimir V Sharoyko
@nl
prefLabel
Vladimir V Sharoyko
@ast
Vladimir V Sharoyko
@en
Vladimir V Sharoyko
@es
Vladimir V Sharoyko
@nl
P106
P1153
9242436300
P31
P496
0000-0002-3717-0471