Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion.
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The transcriptional co-repressor myeloid translocation gene 16 inhibits glycolysis and stimulates mitochondrial respirationRoles of Pyruvate, NADH, and Mitochondrial Complex I in Redox Balance and Imbalance in β Cell Function and DysfunctionMitochondrial pyruvate transport: a historical perspective and future research directionsCNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretionStreptozotocin-induced type 1 diabetes in rodents as a model for studying mitochondrial mechanisms of diabetic β cell glucotoxicityMathematical model of metabolism and electrophysiology of amino acid and glucose stimulated insulin secretion: in vitro validation using a β-cell lineMitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secretionOxamate Improves Glycemic Control and Insulin Sensitivity via Inhibition of Tissue Lactate Production in db/db MicePlasma membrane potential oscillations in insulin secreting Ins-1 832/13 cells do not require glycolysis and are not initiated by fluctuations in mitochondrial bioenergetics.Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretionIncreased glucose metabolism and glycerolipid formation by fatty acids and GPR40 receptor signaling underlies the fatty acid potentiation of insulin secretionSox5 regulates beta-cell phenotype and is reduced in type 2 diabetesMitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic β-cells.Regulation of insulin secretion: role of mitochondrial signalling.Glucose sensing in the pancreatic beta cell: a computational systems analysis.Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells.Comparative Analysis of the Mitochondrial Physiology of Pancreatic β CellsEstrogen regulates energy metabolic pathway and upstream adenosine 5'-monophosphate-activated protein kinase and phosphatase enzyme expression in dorsal vagal complex metabolosensory neurons during glucostasis and hypoglycemia.Stimulus-induced S-nitrosylation of Syntaxin 4 impacts insulin granule exocytosisDNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients.DNA methylation directs functional maturation of pancreatic β cells.Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes.Glutathionylation state of uncoupling protein-2 and the control of glucose-stimulated insulin secretion.Role of non-coding RNAs in pancreatic beta-cell development and physiology.Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell.Characterization of stimulus-secretion coupling in the human pancreatic EndoC-βH1 beta cell line.Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion.The Pancreatic β-Cell: A Bioenergetic Perspective.Advanced bile acid-based multi-compartmental microencapsulated pancreatic β-cells integrating a polyelectrolyte-bile acid formulation, for diabetes treatment.Transglutaminase 2 reprogramming of glucose metabolism in mammary epithelial cells via activation of inflammatory signaling pathways.Chronic high glucose and pyruvate levels differentially affect mitochondrial bioenergetics and fuel-stimulated insulin secretion from clonal INS-1 832/13 cells.Traditional and novel tools to probe the mitochondrial metabolism in health and disease.Novel insights into pancreatic β-cell glucolipotoxicity from real-time functional analysis of mitochondrial energy metabolism in INS-1E insulinoma cells.Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity.Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal β-cell lines.Bioenergetic profile experiment using C2C12 myoblast cells.Reduction of reactive oxygen species ameliorates metabolism-secretion coupling in islets of diabetic GK rats by suppressing lactate overproduction.Transcribing β-cell mitochondria in health and disease.Chronic Exposure to Proline Causes Aminoacidotoxicity and Impaired Beta-Cell Function: Studies In Vitro.IL-1β hampers glucose-stimulated insulin secretion in Cohen diabetic rat islets through mitochondrial cytochrome c oxidase inhibition by nitric oxide.
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Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion.
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 21 September 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Tight coupling between glucose ...... for robust insulin secretion.
@en
Tight coupling between glucose ...... for robust insulin secretion.
@nl
type
label
Tight coupling between glucose ...... for robust insulin secretion.
@en
Tight coupling between glucose ...... for robust insulin secretion.
@nl
prefLabel
Tight coupling between glucose ...... for robust insulin secretion.
@en
Tight coupling between glucose ...... for robust insulin secretion.
@nl
P2093
P2860
P50
P921
P356
P1476
Tight coupling between glucose ...... for robust insulin secretion.
@en
P2093
Ashkan Tamaddon
David G Nicholls
Rolf Wibom
Thomas Koeck
P2860
P304
32395-32404
P356
10.1074/JBC.M109.026708
P407
P577
2009-09-21T00:00:00Z