about
Fourier analysis and systems identification of the p53 feedback loopFlexible CRISPR library construction using parallel oligonucleotide retrieval.A synthetic-natural hybrid oscillator in human cellsp53 dynamics control cell fateBasal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.Robustness and the cycle of phosphorylation and dephosphorylation in a two-component regulatory system.Far Upstream Element Binding Protein Plays a Crucial Role in Embryonic Development, Hematopoiesis, and Stabilizing Myc Expression Levels.p53 Pulses Diversify Target Gene Expression Dynamics in an mRNA Half-Life-Dependent Manner and Delineate Co-regulated Target Gene Subnetworks.Continuous control in bacterial regulatory circuits.Disabled cell density sensing leads to dysregulated cholesterol synthesis in glioblastoma.Determining the Limitations and Benefits of Noise in Gene Regulation and Signal Transduction through Single Cell, Microscopy-Based Analysis.Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage.Promoter decoding of transcription factor dynamics.Single-cell Gene Expression Profiling Using FACS and qPCR with Internal Standards.Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response.CRISPR/Cas9-mediated gene knockout is insensitive to target copy number but is dependent on guide RNA potency and Cas9/sgRNA threshold expression level.NFκB Promotes Ovarian Tumorigenesis via Classical Pathways That Support Proliferative Cancer Cells and Alternative Pathways That Support ALDH+ Cancer Stem-like Cells.Using computational modeling and experimental synthetic perturbations to probe biological circuits.Recent progress and open challenges in modeling p53 dynamics in single cells.Modeling cell heterogeneity: from single-cell variations to mixed cellsp53 pulse modulation differentially regulates target gene promoters to regulate cell fate decisionsProtein stability of p53 targets determines their temporal expression dynamics in response to p53 pulsing
P50
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P50
description
researcher ORCID ID = 0000-0003-3870-5615
@en
wetenschapper
@nl
name
Eric Batchelor
@ast
Eric Batchelor
@en
Eric Batchelor
@es
Eric Batchelor
@nl
type
label
Eric Batchelor
@ast
Eric Batchelor
@en
Eric Batchelor
@es
Eric Batchelor
@nl
prefLabel
Eric Batchelor
@ast
Eric Batchelor
@en
Eric Batchelor
@es
Eric Batchelor
@nl
P106
P31
P496
0000-0003-3870-5615