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Mechanistic Modeling Reveals the Critical Knowledge Gaps in Bile Acid-Mediated DILIA multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicityAssessment of gadoxetate DCE-MRI as a biomarker of hepatobiliary transporter inhibitionSystems toxicology: modelling biomarkers of glutathione homeostasis and paracetamol metabolism.Multiple compound-related adverse properties contribute to liver injury caused by endothelin receptor antagonists.In vitro exploration of potential mechanisms of toxicity of the human hepatotoxic drug fenclozic acid.In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs.In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.Quantification of Drug-Induced Inhibition of Canalicular Cholyl-l-Lysyl-Fluorescein Excretion From Hepatocytes by High Content Cell Imaging.Systems pharmacology modeling of drug-induced hyperbilirubinemia: Differentiating hepatotoxicity and inhibition of enzymes/transporters.Tumor agonist peptides break tolerance and elicit effective CTL responses in an inducible mouse model of hepatocellular carcinoma.Molecular fingerprinting and autocrine growth regulation of endothelial cells in a murine model of hepatocellular carcinoma.Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug ToxicityUsing quantitative systems toxicology to investigate observed species differences in CKA-mediated hepatotoxicityA novel multi-parametric high content screening assay in ciPTEC-OAT1 to predict drug-induced nephrotoxicity during drug discoveryNuclear hormone receptor-dependent regulation of hepatic transporters and their role in the adaptive response in cholestasisPerspective on the Application of Microphysiological Systems to Drug Transporter StudiesThe analysis of acetaminophen (paracetamol) and seven metabolites in rat, pig and human plasma by U(H)PLC-MS
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description
researcher ORCID ID = 0000-0001-9039-9067
@en
wetenschapper
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name
Simone H Stahl
@ast
Simone H Stahl
@en
Simone H Stahl
@es
Simone H Stahl
@nl
type
label
Simone H Stahl
@ast
Simone H Stahl
@en
Simone H Stahl
@es
Simone H Stahl
@nl
prefLabel
Simone H Stahl
@ast
Simone H Stahl
@en
Simone H Stahl
@es
Simone H Stahl
@nl
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54793606600
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0000-0001-9039-9067