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Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundleGermline mutations in the thyrotropin receptor gene cause non-autoimmune autosomal dominant hyperthyroidismSite-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptorStructures of the intradiskal loops and amino terminus of the G-protein receptor, rhodopsinFunctional role of internal water molecules in rhodopsin revealed by X-ray crystallography.Biophysical methods to study ligand-receptor interactions of neuropeptide YA large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzledKnowledge-Based Protein ModelingModeling of the structural features of integral-membrane proteins reverse-environment prediction of integral membrane protein structure (REPIMPS)Molecular modelling of drug targets: the past, the present and the future.Membrane protein structure: the contribution and potential of novel solid state NMR approaches.Trifluoroethanol and binding to model membranes stabilize a predicted turn in a peptide corresponding to the first extracellular loop of the angiotensin II AT(1A) receptor.Conserved aromatic residues in the transmembrane region VI of the V1a vasopressin receptor differentiate agonist vs. antagonist ligand binding.Magic angle spinning NMR of the protonated retinylidene Schiff base nitrogen in rhodopsin: expression of 15N-lysine- and 13C-glycine-labeled opsin in a stable cell line.High affinity agonistic metal ion binding sites within the melanocortin 4 receptor illustrate conformational change of transmembrane region 3.Functional architecture of vasopressin/oxytocin receptors.7 Å resolution in protein two-dimensional-crystal X-ray diffraction at Linac Coherent Light Source.Constitutive activation of the delta opioid receptor by mutations in transmembrane domains III and VII.Molecular basis of ligand binding and receptor activation in the oxytocin and vasopressin receptor family.Electron and atomic force microscopy of the trimeric ammonium transporter AmtB.Comparative analysis of the heptahelical transmembrane bundles of G protein-coupled receptors.Peptide hormone binding to G-protein-coupled receptors: structural characterization via NMR techniques.Modeling the 3D structure of GPCRs from sequence.Characterisation of the ultraviolet-sensitive opsin gene in the honey bee, Apis mellifera.Drug analysis based on signaling responses to G-protein-coupled receptors.Molecular Architecture of G Protein-Coupled Receptors.Conformational changes of G protein-coupled receptors during their activation by agonist binding.Heavier-than-air flying machines are impossible.Time-resolved structural studies with serial crystallography: A new light on retinal proteins.Disruption of Rhodopsin Dimerization with Synthetic Peptides Targeting an Interaction InterfaceFrom genomics to drug targets.Conversion of agonist site to metal-ion chelator site in the beta(2)-adrenergic receptor.Novel "restoration of function" mutagenesis strategy to identify amino acids of the delta-opioid receptor involved in ligand binding.Advances in the Development and Application of Computational Methodologies for Structural Modeling of G-Protein Coupled Receptors.An overview of recent developments in GPCR modelling: methods and validation.GPCR: G protein complexes--the fundamental signaling assembly.Parathyroid hormone-receptor interactions identified directly by photocross-linking and molecular modeling studies.Probing the structure and function of the tachykinin neurokinin-2 receptor through biosynthetic incorporation of fluorescent amino acids at specific sites.Agonist recognition by proteinase-activated receptor 2 and thrombin receptor. Importance of extracellular loop interactions for receptor function.Expanding the horizons of G protein-coupled receptor structure-based ligand discovery and optimization using homology models.
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P2860
description
article publié dans la revue scientifique Nature
@fr
scientific article published in Nature
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в Nature у квітні 1993
@uk
name
Projection structure of rhodopsin
@en
Projection structure of rhodopsin
@nl
type
label
Projection structure of rhodopsin
@en
Projection structure of rhodopsin
@nl
prefLabel
Projection structure of rhodopsin
@en
Projection structure of rhodopsin
@nl
P356
P1433
P1476
Projection structure of rhodopsin
@en
P2093
P2888
P304
P356
10.1038/362770A0
P407
P577
1993-04-01T00:00:00Z
P6179
1018212967